Mechanical Ventilation Complication, Pediatric Respiratory Diseases
Conditions
Keywords
Pediatric Critical Care, Respiratory Mechanics, Tracheal Suctioning, Mechanical ventilation
Brief summary
The purpose of this study is to evaluate the efficacy of tracheal suctioning associate with expiratory pause maneuver in children on invasive mechanical ventilation.
Detailed description
After being informed about the study and potential risks, all parents or guardians giving written informed consent will be evaluate for study entry. Children in invasive mechanical ventilation who meet eligibility criteria will be submitted of two techniques of tracheal suctioning (with and without expiratory pause maneuver), randomized in a crossover trial in a 1:1 ratio, for determine the first technique to be applied. Clinical data will be collected (sex, age, presence of previous disease, diagnosis of hospitalization), as well as the ventilatory parameters (ventilation mode, peak inspiratory pressure, positive end-expiratory pressure, tidal volume, respiratory frequency, fraction of inspired oxygen). The protocol consists of an initial conventional tracheal suctioning with a negative pressure of 40mmHg for all the participants. After two (2) hours the first technique will be applied and an interval of another two hours for the application of the second technique. Respiratory mechanics and hemodynamic parameters will be evaluate before and after 30 minutes of each tracheal suctioning techniques. In case of clinical alterations that may aggravate the patients condition during the protocol (oxygen saturation \< 85%, heart rate \> 190bpm and/or decrease 20% of mean arterial blood pressure), the technique will be interrupted immediately and the patient will be evaluated.
Interventions
OTHEREndotracheal suctioning with expiratory pause
Perform closed endotracheal suctioning with an expiratory pause of 5 seconds
OTHEREndotracheal suctioning without expiratory pause
Perform closed endotracheal suctioning without expiratory pause
Sponsors
Hospital de Clinicas de Porto Alegre
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
1 Months to 2 Years
Healthy volunteers
No
Inclusion criteria
* Children at invasive mechanical ventilation for more than 24 hours; * Under the effect of neuromuscular blocker (level of sedation assessed using the Comfort B Scale with a score \<10 and without a cough reflex); * Endotracheal suctioning in a period \> 2h before the application of the technique.
Exclusion criteria
* Patients with undrained pneumothorax or hemothorax, or presence of subcutaneous emphysema; * Hemodynamic instability (hypotension refractory to treatment) * Need of frequent endotracheal suctioning
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weight of endotracheal suctioning | Immediately after suctioning | Weight of endotracheal suctioning in milligrams |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tidal volume | Baseline and 30 minutes | Tidal volume in milliliters (ml) |
| Dynamic compliance | Baseline and 30 minutes | Dynamic compliance in milliliters per kilograms per centimeters of water (mL/kg/cmH2O) |
| Airway resistance | Baseline and 30 minutes | Inspiratory and expiratory resistance in centimeters of water per liter (cmH2O/L) |
| Auto-positive end-expiratory pressure (auto-PEEP) | Baseline and 30 minutes | Auto-PEEP in centimeters of water (cmH2O) |
| Peak inspiratory pressure | Baseline and 30 minutes | Peak inspiratory pressure in centimeters of water (cmH2O) |
| Plateau pressure | Baseline and 30 minutes | Plateau pressure in centimeters of water (cmH2O) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Oxygen saturation | Baseline, immediately after suctioning and after 30 minutes | Oxygen saturation in percentage (%) |
| Heart rate | Baseline, immediately after suctioning and after 30 minutes | Heart rate in beats per minute (bpm) |
| Arterial blood pressure | Baseline, immediately after suctioning and after 30 minutes | Systolic and diastolic blood pressure in millimeters of mercury (mmHg) |
Countries
Brazil
Outcome results
None listed