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Testing the Persuasiveness of Pro-inoculation Arguments

Message Testing Protocol for Misinformation Concerns

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05804825
Enrollment
523
Registered
2023-04-07
Start date
2023-05-04
Completion date
2023-05-24
Last updated
2023-07-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Human Papillomavirus Vaccination, Vaccination Hesitancy, Vaccine Refusal

Keywords

misinformation, HPV vaccine, vaccine hesitancy

Brief summary

The investigators will recruit a national sample of parents of 7-10-year-olds to complete an argument strength ranking for either a simple forwarding message or between 3 and 6 randomly selected arguments from an overall set of 50 to 100 messages identified from various online sources. Parents will rate each message they see on measures of perceived argument strength/PME. Parents will also answer sociodemographic questions and then rank the believability of a set of anti-vaccine messages identified in a different study. Study findings will contribute valuable information to understanding the effectiveness of different inoculation messages.

Interventions

BEHAVIORALArgument inoculation messages

Participants will then be presented with arguments randomly selected by the Qualtrics software algorithm from the full set of messages.

BEHAVIORALSimple forewarning message

Participants will be presented with a simple forewarning message.

Sponsors

University of Pennsylvania
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE

Intervention model description

randomized discrete choice modeling experiment design

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

1. Male or female parent or legal guardian of an adolescent ages 7-10 2. Age eligible child has not yet received any doses of the HPV vaccine 3. Resides in the United States 4. English speaking 5. Completed informed consent

Exclusion criteria

1. Unable to read English at a 6th grade literacy level 2. Age \< 18 3. Does not have a child within the age range of 7-10 4. Age-eligible child has received 1 or more doses of the HPV vaccine 5. Does not have a social media account on one or more of the following platforms OR does not read online news stories: Twitter, Instagram, YouTube, Facebook (feasibility testing only - survey participation will not have this

Design outcomes

Primary

MeasureTime frameDescription
Argument strength/PMEThe outcome measure will be assessed immediately after the participant has viewed each pro-HPV vaccine message if they are in the multiple message condition, or the simple message if they are in the simple message condition stimuli during the survey.Arguments will be rated for their argument strength/message effectiveness
Misinformation believabilityThe outcome measure will be assessed immediately after the participant has viewed each misinformation message during the survey.A rating of the believability/ credibility of vaccine misinformation

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026