Bone Loss, Bone Resorption, Femoral Neck Fractures, Muscle Damage, Muscle Loss, Pertrochanteric Fracture
Conditions
Keywords
proximal femur fracture, femoral neck fracture, pertrochanteric fracture, bone intake proteins, bone resorption, bone loss, muscle damage, muscle loss
Brief summary
The aim of this clinical trial is to compare serum concentration of bone intake proteins \[ sex hormone-binding globulin (SHBG), cross linked C-telopeptide of type I collagen (CTX-I)\] and muscle atrophy marker \[creatine kinase (CK-MB)\] between patients after the fracture of proximal femur and their age corresponding counterpart without the fracture. The main question it aims to answer is: • Is the higher concentration of bone intake proteins and muscle atrophy marker a predictive factor of proximal femur fracture? The part of participants (Group 1) will be hospitalized at the Department of Orthopaedics and Rehabilitation and will undergo a surgical treatment (open reduction of the fracture). The rest (Group 2) will be admitted to the Department of Internal Medicine. Participants of both Groups will have the blood sample test taken, to evaluate and compare the serum concentration of SHBG, CTX-I and CK-MB proteins.
Interventions
PROCEDURESurgical treatment of proximal femur fracture and blood sample test
Open reduction of femoral neck or pertrochanteric fracture with hemi/total hip arthroplasty or gamma nail. Analysis of serum concentration of: SHBG, CTX - I, CK-MB
PROCEDUREBlood sample test
Analysis of serum concentration of: SHBG, CTX - I, CK-MB
Sponsors
Medical University of Warsaw
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age over 65 * Proximal femur fracture (Group 1)
Exclusion criteria
* neoplasmatic history in the anamnesis, * prevalent fracture * mental illness * immune disease affecting protein balance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum concentration of SHBG and comparison between intervention groups | (Group 1) At the day of the admission to the Department of Orthopaedics and Rehabilitation prior the surgical treatment or (Group 2) at the day of the admission to the Department of Internal Medicine |
| Serum concentration of CTX-I and comparison between intervention groups | (Group 1) At the day of the admission to the Department of Orthopaedics and Rehabilitation prior the surgical treatment or (Group 2) at the day of the admission to the Department of Internal Medicine |
| Serum concentration of CK-MB and comparison between intervention groups | (Group 1) At the day of the admission to the Department of Orthopaedics and Rehabilitation prior the surgical treatment or (Group 2) at the day of the admission to the Department of Internal Medicine |
Countries
Poland
Outcome results
None listed