Autism Spectrum Disorder
Conditions
Brief summary
Evaluate some Inflammatory markers \[IL-6, IL-8, TNF\_alpha\] in children with autism spectrum disorder
Detailed description
several studies have suggested a correlation between ASD and abnormal immune activation (9) For instance, there is a high incidence of autistic subjects in families with other autoimmune disorders such as celiac disease and rheumatoid arthritis, suggesting a potential role for immune dysfunction in the pathophysiology of ASD High levels of IL-6 in the brain could determine alterations of synapse formation, dendritic spine development, and neuronal circuit balance \[13\], while in plasma they have been associated with increased stereotypical behaviors and with regressive forms of ASD
Interventions
OTHERinflammatory marker in autism spectrum disorder
Evaluate some Inflammatory markers \[IL-6, IL-8, TNF\_alpha\] in children with autism spectrum disorder
Sponsors
Assiut University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 18 Years
Inclusion criteria
* 50 patients aged 3\_18 years, equally sex distributed, who visit pediatric neurology outpatients clinic with autistic disorder at assiut university hospital will enrolled in this study and 50 controls . (According to DSM IV and ADT-R)
Exclusion criteria
* : Asperger syndrome, pervasive developmental disorder not otherwise specified (PDD-NOS), chronic seizures and recent infection and patients with congenital anomalies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| inflammatory marker in autism | baseline | Evaluate some Inflammatory markers \[IL-6, IL-8, TNF\_alpha\] in children with autism spectrum disorder |
Contacts
Primary Contactghada ali, graduated
Backup Contacteman fathalla, ass.prof
Outcome results
None listed