Post Operative Pain
Conditions
Keywords
mastectomy, postoperative pain, serratus anterior block, adjuvants
Brief summary
This study is designed to investigate the analgesic efficacy of ketamine compared to neostigmine as adjuvants to LA in ultrasound guided Serratus Anterior Plane Block (SAPB) in patients undergoing Modified Radical Mastectomy. We hypothesize that adding either neostigmine or ketamine to bupivacaine in ultrasound guided SAPB would increase the total analgesic duration and decrease the total 24 hr postoperative Nalbuphine consumption compared to SAPB with bupivacaine only. The first 24 hr of postoperative Nalbuphine consumption is set as the primary outcome. The time of the first request of analgesia, pain score, side effects of drugs and patient hemodynamics are set as the secondary outcomes.
Interventions
DRUGAdjuvants, Anesthesia
testing the effect of adding ketamine versus neostigmine to the analgesic efficacy of serratus anterior plane block in modified radical mastectomy surgeries
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* ASA II patients, BMI\< 35Kg/m2
Exclusion criteria
* refusal of participation, ASA III or above, history of allergy to the study drugs, BMI\> 35kg/m2, coagulation disorders, psychiatric illnesses that may interfere with pain evaluation, epileptic patients, patients with tachy or brady arrthymias, patients with increased intracranial tension
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| analgsic consumption | first 24 hours postoperative | total amount of consumed nalbuphine |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| time to rescue analgesia | first 24 hours postoperative | first time to request rescue analgesia |
| pain scores | first 24 hours postoperative | pain scores measured by numerical pain score chart |
Countries
Egypt
Outcome results
None listed