The Biomechanical Study of Diseased Human Carotid, Femoral and Abdominal Aortic Tissue

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05802706

Enrollment

300

Registered

2023-04-06

Start date

2016-01-01

Completion date

2027-01-01

Last updated

2025-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vascular Diseases

Brief summary

This cross-sectional study aims to ascertain the mechanical properties of human carotid/femoral atherosclerotic plaque and abdominal aortic aneurysm tissue and correlate tissue mechanics with novel blood-based biomarkers of cardiovascular calcification.

Detailed description

The study is a non-randomised, controlled, cross-sectional study of diseased human carotid, femoral and abdominal aortic tissue.

Interventions

OTHERNo intervention.

No intervention.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with arterial plaque undergoing treatment where the plaque tissue will be surgically removed as per the usual peripheral endarterectomy procedure. * Able to provide informed consent.

Exclusion criteria

* Patients that are unable to give informed consent. * Seriously ill/unconscious patients.

Design outcomes

Primary

Measure	Time frame	Description
Calcification feature classification	10 years	Identification of particular calcification features of plaque tissue and their influence on mechanical properties which may help clarify the success of stenting in certain patient cohorts compared to others and elucidate the procedural risk of endovascular treatments in plaque with certain calcification types.
Biomarker Analysis	10 years	Identification of novel biomarkers of vascular calcification could potentially be used as a predictive tool to highlight those at greatest risk of adverse peri-operative events, to allow for tailored medical treatment approaches and to stream-line patient care and improve patient outcomes.

Secondary

Measure	Time frame	Description
Cardiovascular Health Critical Mass	10 years	To build a critical mass in cardiovascular health, an area of strategic importance for healthcare in Ireland.

Countries

Ireland

Contacts

Primary ContactFiona Leahy, MSc

fionac.leahy@hse.ie061 301111

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026