Acute ST Segment Elevation Myocardial Infarction, Inflammation, Prognosis
Conditions
Brief summary
By including patients with acute myocardial infarction, mast cell markers were analyzed and the relationship between mast cells and patients with acute myocardial infarction was analyzed
Detailed description
Percutaneous coronary intervention (PCI) is the best way to improve the prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI). However, ischemia reperfusion injury, inappropriate ventricular remodeling, and myocardial fibrosis may still be present in STEMI after PCI, which may be related to the inflammatory response in STEMI. Mast cells (MC), their degranulation products and induction of a series of inflammatory cytokines play an important role in the inflammatory response. The purpose of this study was to evaluate the relationship between mast cell markers (trypsin, chymotrypsin) levels and prognosis after direct PCI in STEMI patients. We prospectively and continuously included STEMI patients undergoing standard therapy after direct PCI. Clinical data and blood samples were collected and followed up for 1 year to analyze mast cell markers and myocardial infarction size. As well as differences in echocardiography, markers of two-dimensional speck tracking techniques, inflammatory factors and major adverse cardiovascular events, to explore the relationship between mast cells and their products and ventricular remodeling and ischemia-reperfusion injury in STEMI patients, and to provide new ideas for treatment and new basis for optimization of STEMI treatment strategies.
Interventions
DIAGNOSTIC_TESTTryptase
Serum samples were collected from patients within 24 hours, 1 month, 3 months and 12 months after myocardial infarction, and trypsin-like enzymes were determined by elisa
Sponsors
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age above 18 years old, regardless of gender; * 2\) Meet STEMI diagnostic criteria (diagnostic criteria: ischemic chest pain lasting ≥30min; ST segment elevation of more than two adjacent leads or new left bundle branch block in ECG; With or without elevated myocardial markers) and receiving standard care for STEMI. * 3\) Agree to and cooperate with the study
Exclusion criteria
* 1\) The patient is taking or planning to take long-term oral or intravenous glucocorticoids (inhaled and topical hormones are allowed); * 2\) Allergic diseases, autoimmune diseases or malignant tumors. * 3\) Patients with metal implants or claustrophobia are not allowed to undergo an MRI examination; * 4\) Pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Myocardial infarct size | 3 months after myocardial infarction | Myocardial infarct size was assessed by cardiac MRI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Left ventricular ultrasound strain | 24 hours, 1 month, 3 months, and 12 months after myocardial infarction | Two-dimensional speckle tracking imaging measures the movement in the long-axis direction as the overall longitudinal strain, the movement in the short-axis direction as the overall radial strain, reflecting the degree of wall systolic thickening, and the annular motion in the short-axis direction as the overall circumferential strain |
| inflammatory marker such as TNF-α | 24 hours, 1 month, 3 months, and 12 months after myocardial infarction | — |
| left ventricular systolic function | 24 hours, 1 month, 3 months, and 12 months after myocardial infarction | Transthoracic echocardiography to measure LVEF, left ventricular end-diastolic diameter, Em/Sm |
| MC marker (chymotrypsin) | 24 hours, 1 month, 3 months, and 12 months after myocardial infarction | — |
| major adverse cardiovascular events | 12 months | MACE events (death, nonfatal myocardial infarction, unplanned revascularization, hospitalization for angina and readmission for heart failure) |
| inflammatory markers e.g. IL1, IL6 | 24 hours, 1 month, 3 months, and 12 months after myocardial infarction | — |
Contacts
Primary ContactPengxin Xie
Backup ContactMing Cui, Doctor
Outcome results
None listed