Lower Back Pain Chronic
Conditions
Keywords
NaF PET, Bone metabolism, Bone perfusion
Brief summary
The main goal of this study is to determine if static or dynamic \[18F\]NaF PET/CT (positron emitting tomography) can identify the source of lower backpain in at least 20% of the patients experiencing lower backpain, yet could not be diagnosed from MRI or CT scans.
Detailed description
Patients with chronic lower backpain are routinely scanned with MR and/or CT to diagnos the source of pain. Larger studies have reported that approximately 20% of patients are given a certain diagnosis from the scans and in the majority of cases the source of the pain is not determined. The use of \[18F\]NaF PET/CT to map bone perfusion and metabolism is a routine clinical scan that can potentially identify the source of lower backpain in MRI and CT negative patients. Hypothesis: That \[18F\]NaF PET/CT bone metabolism and bone perfusion images would contain information that allow the correct diagnosis in at least 20% of patients where MRI and CT images did not reveal pathology.
Interventions
DIAGNOSTIC_TEST[18F]NaF PET/CT scan
Patients will have their lower back scanned using \[18F\]NaF PET/CT
Sponsors
Herlev Hospital
Rigshospitalet, Denmark
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Over 18 years * Chronic lower back pain with no concrete diagnosis after MRI and/or CT * Under the the care of Rigshospitalets centre for Rheumatology and Spine Disease
Exclusion criteria
* previous operation in the lower back area * Known inflammatory related illness or progressive rheumatism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Abnormal foci of elevated bone metabolism, blood pooling or bone perfusion | 1 hour examination | \[18F\]NaF PET/CT scan |
Countries
Denmark
Outcome results
None listed