Chronic Obstructive Pulmonary Disease
Conditions
Brief summary
The goal of observational study is to Evaluation of the effectiveness of the self-developed pulmonary lobar ventilation detector in Chronic Obstructive Pulmonary Disease. The main question it aims to answer are:Evaluation of the effectiveness of the self-developed pulmonary lobar ventilation detector. Participants will use the self-developed pulmonary lobar ventilation detector and the imported Chartis detection system to evaluate the target pulmonary lobar collateral ventilation.
Interventions
DEVICESelf-developed pulmonary lobar ventilation detector
The participants would evaluated by the self-developed pulmonary lobar ventilation detector.
DEVICEChartis detection system
The participants would evaluated by the Chartis detection system.
Sponsors
China-Japan Friendship Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients with chronic obstructive pulmonary disease who meet the GOLD diagnostic criteria * FEV1 ≤ 45% pred and FEV1/FVC\<70% * TLC\>100% pred and RV\>175% pred * CAT≥18 * \>50% of emphysema destruction * Smoking prohibition\>6 months * Sign the informed consent form
Exclusion criteria
* PaCO2\>8.0 kPa, or PaO2\<6.0 kPa * 6-minute walking test\<160m * Obvious chronic bronchitis, bronchiectasis or other infectious lung diseases * Three hospitalizations due to pulmonary infection in the past 12 months before the baseline assessment * Previous lobectomy, LVRS or lung transplantation * LVEF\<45% and or RVSP\>50mmHg * Anticoagulant therapy that cannot be stopped before surgery * The patient has obvious immune deficiency * Participated in other lung drug studies within 30 days before this study * Pulmonary nodules requiring intervention * Any disease or condition that interferes with the completion of the initial or subsequent assessment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Therapeutic effect of lung volume reduction surgery | 1 month after bronchoscopic valve lung volume reduction | Lung CT |
| the integrity of interlobar fissure | Before bronchoscopic valve lung volume reduction | Use the self-developed pulmonary lobar ventilation detector and the imported Chartis detection system to evaluate the target pulmonary lobar collateral ventilation |
Countries
China
Contacts
Primary ContactMingming Deng, MD
Outcome results
None listed