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Effect of Covid-19 on Hypertension

The Long-term Impact of COVID-19 on Blood Pressure: A Retrospective Cohort Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05798208
Enrollment
5355
Registered
2023-04-04
Start date
2020-02-15
Completion date
2023-02-20
Last updated
2023-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19, Hypertension

Keywords

covid-19, hypertension, blood pressure

Brief summary

In this single center , retrospective study, 5355 covid patient were selected from 2020 to 2022, with recorded blood pressure before covid and recording after covid. Blood pressure before and after covid were compared, by pair T test.

Detailed description

design and participants This single-center retrospective cohort study was conducted at an outpatient cardiology clinic in Shiraz, Iran, between February 15, 2020, and December 28, 2022. We evaluated patients with a confirmed diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by RNA reverse-transcriptase polymerase-chain-reaction assays from nasopharyngeal or oropharyngeal swab specimens according to World Health Organization guidelines (12). Two physicians (PA, MY) reviewed the patients' electronic medical records, including demographics, comorbidities, vital signs, treatments, and outcomes. Ambiguities were resolved by a third author (MM). The current study included all COVID-19 patients who had at least one documented blood pressure measurement in the three months preceding infection and one documented measurement one to three months following recovery. The following patients were excluded: those under 18, with hospital admission due to COVID-19, who received corticosteroid therapy, those with a history of systemic inflammatory disease, kidney or liver, immunocompromised patients, and those who switched their antihypertensive regimen during the study. Finally, 5,355 eligible patients were investigated . The primary outcome was to assess BP variation following infection (particularly a prolonged rise in BP) among non-hospitalized COVID-19 patients. The secondary outcome was to identify the predictor factors of BP variation. The present study was approved by the Ethics Committee of Shiraz University of Medical Sciences under code IR.SUMS.MED.REC.1401.465 , and the need for informed consent was waived due to the study's retrospective nature and the absence of patient identifiers in the presented data.

Interventions

DIAGNOSTIC_TESTblood pressure measurement

Taking blood pressure with automated arm sphygmomanometer and pressure higher than 140/90 was considered abnormal

Sponsors

Shiraz University of Medical Sciences
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
39 Years to 71 Years

Inclusion criteria

* All COVID-19 patients who had at least one documented blood pressure measurement in the three months preceding infection and one documented measurement one to three months following recovery

Exclusion criteria

* Age under 18 * Hospital admission due to COVID-19 * Corticosteroid therapy, * History of systemic inflammatory disease * kidney disease * liver disease * Immunocompromised patients

Design outcomes

Primary

MeasureTime frameDescription
change of blood pressure2 yearsany change in blood pressure level before and after covid infection

Secondary

MeasureTime frameDescription
predictors of changes in blood pressure2 yearshistory of any risk factor for cardiac disease, age, sex,

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 8, 2026