Inflammation Process, Endothelial Dysfunction, Vasomotor Arterial Disorder, Vascular Dilation, Swelling; Hand
Conditions
Keywords
Intensive Care, Surgical, Ultrasonography, Doppler, Inflammation
Brief summary
The aim of this study was to measure whether the flow rate through the brachial artery and inflammatory markers were associated with the development of tissue edema in the surgical intensive care unit patients.
Detailed description
The study was performed using a ultrasound machine with linear probe settings at 50 mm depth and 40 decibel \[dB\] gain that did not change during the study. The probe was placed on vascular ultrasound measurement. The diameter of the brachial artery in the middle of the upper arm and the flow rate through the artery was measured on postoperative days 1 and 2. The presence of the edema was measured above the 3rd metacarpal bone as the distance from the skin surface to the periosteum. An average of three assessments was shown. Patient's age, body mass index (BMI), type of admission, white blood cells (WBC), C-reactive protein (CRP), and procalcitonin (PCT) were also registered.
Interventions
DIAGNOSTIC_TESTUltrasound measurement
Study was conducted with Mindray T7 ultrasound machine using linear probe. Vascular ultrasound mode was used with settings depth of 50 mm and gain of 40 dB during the entire study period. The diameter and flow velocity of the brachial artery and wrist edema of the fist were measured within 24 hours of admission and the following day.
Sponsors
Josip Juraj Strossmayer University of Osijek
Osijek University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults over 18 years of age * Postoperative surgical patients * Signed informed consent
Exclusion criteria
* Refusal to give informed consent * A previous thromboembolic event of the brachial artery * Acute infection of the upper extremity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diameter of brachial artery - 1 | within 4 hours of admission. | Measurement of a brachial artery diameter \[cm\] at admission. Admission day is considered as day 1. |
| Diameter of brachial artery - 2 | day 2 after admission is between 24 and 48 hours after admission. | measurement of a brachial artery diameter \[cm\] on day 2 after admission. |
| Brachial artery flow velocity - 1 | within 4 hours of admission to ICU. | measurement of a brachial artery flow velocity \[cm/s\] at admission. |
| Brachial artery flow velocity - 2 | day 2 after admission is between 24 and 48 hours after admission. | measurement of a brachial artery flow velocity \[cm/s\] on day 2 after admission. Day 2 is Measurement of a brachial artery flow velocity \[cm/s\] between 24 and 48 h after ICU admission. |
| Distance from skin to third metacarpal bone -1 | within 4 hours of admission. | measurement of a distance from the skin to third metacarpal bone (cm) at admission. |
| Distance from skin to third metacarpal bone - 2 | day 2 after admission is between 24 and 48 hours after admission. | measurement of a distance from the skin to third metacarpal bone (cm) on day 2 after admission. |
| White blood cell count - 1 | within 4 hours of admission. | blood sample analysis for white blood cell count (WBC \[10\^9/L\]) at admission. |
| White blood cell count - 2 | day 2 after admission is between 24 and 48 hours after admission. | blood sample analysis for white blood cell count (WBC \[10\^9/L\]) on day 2 after admission. |
| C-reactive protein - 1 | within 4 hours of admission. | blood sample analysis for C-reactive protein (CRP \[mg/L\]) concentration at admission. |
| C-reactive protein - 2 | day 2 after admission is between 24 and 48 hours after admission. | Blood sample analysis for C-reactive protein (CRP \[mg/L\]) concentration on day 2 after admission. |
| Procalcitonin - 1 | within 4 hours of admission. | blood sample analysis for Procalcitonin concentration (PCT \[ug/L\]) at admission. |
| Procalcitonin - 2 | Day 2 after admission is between 24 and 48 hours after admission. | Blood sample analysis for Procalcitonin concentration (PCT \[ug/L\]) on day 2 after admission. |
Countries
Croatia
Outcome results
None listed