Acutely Ill, Functional Decline, Gait Speed, Hospitalisation, Muscle Architecture, Older Adults, Physical Performance, Resistance Training, Sarcopenia, Ultrasound
Conditions
Brief summary
Sarcopenia characterised by loss of muscle mass, muscle strength and physical performance burdens many older adults since the condition is related to functional decline. Periods of inactivity such as during hospitalisation leads to further functional decline. It has been reported that the loss of muscle mass associated with sarcopenia not only entails a decrease in muscle mass but also changes in muscle architecture. Knowledge on changes in muscle architecture is essential since it is one of the most important determinants on muscle strength and thus physical performance. The main objective of this study is to investigate changes in muscle architecture and physical performance during acute hospitalisation and after discharge in older adults and subsequently the effectiveness of resistance training of the lower limb during acute hospitalisation. If successful, our study could have a great impact on the individual, as well as societal level, due to a better understanding of the factors related to sarcopenia and the prevention of functional decline as a result of hospitalisation.
Interventions
OTHERResistance training
Moderate resistance training by a innovative training robot 2 times a day during hospitalisation
Sponsors
University of Copenhagen
Nottingham University Hospitals NHS Trust
Odense University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* ≥65 years of age * Able to ambulate before hospitalization (with/without assistance) * Able to communicate with the research team * Expected length of stay ≥2 days * Residing on Funen
Exclusion criteria
* Able to ambulate without assistance during current hospitalization * Known severe dementia * Positive Confusion and Assessment Method score * Patients who have received less than 3 resistance training sessions at discharge * Terminal illness * Recent major surgery or lower extremity bone fracture in the last 3 months * Conditions contradicting use of ROBERT(unstable vertebral-, pelvic, or lower extremity fractures * high intracranial pressure * pressure ulcers or risk of developing pressure ulcers due to fragile skin * patients with medical instability) * Metastases at femur hip * Deemed not suitable for resistance training sessions with the robot by the healthcare professional.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline B-mode ultrasonography | Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week). | Muscle architecture of the m Vastus Lateralis assessed with B-mode ultrasonography. |
| Change from baseline 4 meter Gait Speed Test | Baseline (Day of hospitalisation) to day of discharge from hospital (an average of a week). | Physical performance evaluated by the 4m Gait Speed test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline Bioimpedance | Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week) | Muscle quantity (kg) on wholebody level evaluated by Bioimpedance |
| Length of hospital stay | Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week) | Number of days hospitalised |
| Change from baseline 30s Chair Stand test | Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week) | Maximal muscle strength of the lower extremities evaluated by the 30s Chair Stand Test or the m30s Chair Stand Test (Modified). |
| Unplanned hospitalisation | Day of discharge from hospital to 3-months follow-up | Patients will be followed through a review of medical records for any unplanned Adminstrative registers will be used to assess any unplanned hospitalisation during the period of inclusion. |
| Individual level of physiotherapy | Baseline (day of hospitalisation) to 3-months follow-up | Adminstrative registers and municipalities health records will be used to assess the individual level of physiotherapy (minutes of consultation) in the period of inclusion. |
| Mortality | Baseline (day of hospitalization) to 3-months follow-up | Administrative registers will be used to assess mortality |
| Change from baseline Barthel-Index 100 (Shahs version) | Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week) | Functional level evaluated by The Barthel-Index 100 (Shahs version) |
Countries
Denmark
Outcome results
None listed