The Association Between SIRI and POD in Older Patients

The Potential Value of Systemic Inflammation Response Index on Postoperative Delirium in Older Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05797194

Enrollment

116

Registered

2023-04-04

Start date

2019-03-01

Completion date

2019-10-31

Last updated

2023-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elderly, Postoperative Delirium, Surgery

Brief summary

Postoperative delirium (POD) remains one of most common complication in elderly patients receiving surgery, which is characterized by acute and fluctuating change in the level of cognition and consciousness. Previous studies have shown that surgery and anesthesia-induced acute peripheral inflammation and neuroinflammation may lead to delirium after surgery. Systemic Inflammation Response Index (SIRI) is a more easily accessible and comprehensive inflammation marker derived from monocyte, neutrophil, and lymphocyte count, which has been investigated to assess the prognosis of cancer and infectious diseases. However, the relationship between SIRI and POD has yet to be investigated.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* Hospital stay of at least 3 days * More than or equal to 65 years old * Elementary education or above * Able to communicate * American Society of Anesthesiologists (ASA) physical status I-III * Mini-mental State Examination (MMSE) scores ≥ 22 points

Exclusion criteria

* Preoperative delirium * Severe mental diseases * Autoimmune-illness, chronic infectious diseases, nervous system diseases and malignancies

Design outcomes

Primary

Measure	Time frame	Description
Confusion assessment method (CAM) score	Baseline (Before surgery)	Positive CAM score means that the patient developed postoperative delirium. While negative CAM score means that the patient did not develop postoperative delirium.
CAM score	Postoperative day 1	Positive CAM score means that the patient developed postoperative delirium. While negative CAM score means that the patient did not develop postoperative delirium.

Secondary

Measure	Time frame	Description
The level of systemic inflammation response index (SIRI) in peripheral blood.	Baseline (Before surgery)	The SIRI was calculated as neutrophil count × monocyte count/lymphocyte count.
Mini-mental State Examination (MMSE) score	Baseline (Before surgery)	MMSE score ranges from 0 to 30 and higher score means better outcome.
MMSE score	postoperative day 1	MMSE score ranges from 0 to 30 and higher score means better outcome.

Countries

China

Outcome results