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Endovascular Treatment of Wide Neck Saccular Cerebral Aneurysms

Endovascular Treatment of Wide Neck Saccular Cerebral Aneurysms

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05796986
Enrollment
40
Registered
2023-04-04
Start date
2022-01-01
Completion date
2024-12-01
Last updated
2024-04-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Wide Neck Saccular Cerebral Aneurysms

Brief summary

Intracranial aneurysm (IA) is a cerebrovascular disorder in which the weakness of a cerebral artery wall causes a localized dilation of the blood vessel. Intracranial aneurysm can develop and rupture, and about 85% of spontaneous subarachnoid hemorrhage (SAH) cases are caused by the rupture of Intracerebral aneurysm. Two treatments are available globally: microsurgical clipping and endovascular treatment. Endovascular treatment of Intracerebral aneurysms using detachable platinum coils ( was introduced in 1990 by Guido Guglielmi, an Italian neurosurgeon ) of different shapes and sizes are deposited into the aneurysm through a microcatheter, which reduces the blood flow and induces thrombus formation . Wide neck aneurysm defined by neck diameter greater than 4 mm or dome-to-neck ratio less than 2 Despite advances in endovascular techniques , the treatment of wide-necked aneurysms remains problematic . Endovascular treatment of intracranial aneurysms is associated with lower morbidity and mortality rates and faster recovery compared with traditional microsurgical clipping. In wide-necked Intracerebral aneurysms, complete coil embolization is often technically difficult owing to the risks of distal coil migration or coil impingement on the parent vessel . Complete coil embolization using a single microcatheter without a supporting device in cases of wide-necked Intracerebral aneurysm is technically difficult. Total occlusion rates have increased recently as a result of the advancement of supporting devices These may include balloon remodeling, use of three-dimensional (3D) coils (Russian Doll Technique), combined use of stents and coils (Stent assisted coiling), flow diverters, use of intrasaccular flow disruption (like WEB), Double catheter Technique or combined extra- and intrasaccular devices.

Interventions

PROCEDUREEndovascular procedure of treatment of wide neck saccular cerebral aneurysm

Endovascular different modalities for occlusion of wide neck saccular cerebral aneurysms include stent assisted coiling or balloon assisted coiling or flow diverter or 3D coiling

Sponsors

Sohag University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* All patients of spontaneous subarachnoid haemorrhage due to ruptured wide neck saccular cerebral aneurysms * unruptured Denovo wide neck saccular cerebral aneurysms

Exclusion criteria

* other forms of cerebral aneurysms rather than saccular type : fusiform and dissecting aneurysms * complex aneurysms : giant and thrombosed aneyrsms * any spontaneous subarachnoid haemorrhage with world fedriation of neurosurgery societies (WFNS) Grade 4&5 * Any patient unfit for general anesethia or has serious renal impairment

Design outcomes

Primary

MeasureTime frameDescription
efficacy of procedure1 yeardegree of aneurysm occlusion classifeid by Raymond Roy classification

Countries

Egypt

Contacts

Primary ContactMohmed A Awesh, assistant lecturer
mohamed.ayman@med.sohag.edu.eg01068368550
Backup ContactMohamed A Abdelaal, Professor

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026