Autism, Autism Spectrum Disorder
Conditions
Brief summary
This study aims to accurately characterise the gut microbiota composition of faeces of children with ASD and compare it with the gut microbiota composition of their neurotypical siblings. In addition it aims to also characterise the metagenome and metabolome of the faeces of both ASD and neurotypical siblings.
Interventions
OTHERStool sample
Stool sample
Sponsors
East Suffolk and North Essex NHS Foundation Trust
Quadram Institute Bioscience
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 10 Years
Healthy volunteers
Yes
Inclusion criteria
* Children of both sexes who are diagnosed with ASD and under the care of ESNEFT who have a neurotypical sibling (either full or half sibling), who share their living environment. This is due to the study requiring stool samples that are from siblings, to control for genes and environment where possible. * Aged 3 years to 10 years old (at time of consent) * Parent/guardian able to consent to participate * Parent/guardian able to complete required surveys (or with accommodated adjustments)
Exclusion criteria
* Use of antibiotics in the previous 4 weeks * Not under the care of ESNEFT * Children \<3 years old and \>10 years old * Children that don't have half or full siblings * Parent/guardian unable to provide informed consent or complete surveys, despite reasonable adjustments being implemented
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gut microbiota | 0 weeks | Gut microbiota composition of faeces of children with ASD |
Countries
United Kingdom
Contacts
PRINCIPAL_INVESTIGATORBen Marlow
East Suffolk and North Essex NHS Foundation Trust
Outcome results
None listed