A Study to Assess the Effects of CT-868 Treatment on Glucose Homeostasis in Participants with Type 1 Diabetes

A Randomized, Double-Blind, Placebo and Comparator-Controlled Crossover Study to Assess the Effects of CT-868 Treatment on Glucose Homeostasis in Participants with Type 1 Diabetes

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05794581

Enrollment

Registered

2023-04-03

Start date

2023-03-21

Completion date

2024-04-06

Last updated

2024-12-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 1 Diabetes

Keywords

Type 1 Diabetes, Obesity, Overweight

Brief summary

This study will be conducted primarily to evaluate the effects of CT-868 on glucose homeostasis in participants with Type 1 Diabetes Mellitus.

Interventions

DRUGCT-868

CT-868

DRUGPlacebo

Placebo as SC Injection

DRUGVictoza

Victoza as active comparator as SC Injection

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Female or male adults with Type 1 diabetes * Ages 18-65 years * Type 1 DM for at least 3 years * Using an insulin pump or multiple daily injections (MDI) for at least 3 months * BMI 25.0 - 35.0

Exclusion criteria

* Significant medical history * Uncontrolled diabetes * History of surgical treatment for weight loss * History of malignancy

Design outcomes

Primary

Measure	Time frame
To assess area under the curve (AUC) in glucose metabolism during MMTT	Baseline up to 4 days

Secondary

Measure	Time frame
To assess changes in continuous glucose monitoring (CGM) measures	Baseline up to 4 days
Area under the acetaminophen concentration-time (AUC)	0 - 300 minutes

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026