Predictors of Node Positivity in Endometrial Cancer

Histological and Molecular Characteristics Predict the Risk of Nodal Involvement in Endometrial Cancer: a Prospective Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05793333

Enrollment

200

Registered

2023-03-31

Start date

2022-01-10

Completion date

2025-01-01

Last updated

2024-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometrial Cancer

Keywords

sentinel node, endometrial cancer

Brief summary

To investigate the role of histological and moleculr profile of endometrial cancer patietns in predicting the risk of nodal metastases in endometrila cancer patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Written informed consent * Histologically confirmed endometrila cancer * Data on molecular genomic profiling (POLE mutated, p53 abnormalities, MMRd/MSI-H, and NSMP) * Data on histological characteristics of the ttumor * Execution of sentinel node mapping * Data on sentinel node status (negative vs. positive)

Exclusion criteria

* Stage IVB endoemtrial cancer * consent withdraw

Design outcomes

Primary

Measure	Time frame	Description
positive nodes	12 months	positive nodes detected by sentinel node mappinig

Countries

Italy

Contacts

Primary ContactGrazia M Casadei, ph.d.

grazia.casadei@istitutotumori.mi.it917-275-6975

Outcome results