Liver Dysfunction, Rejection Acute Hepatic, Transplant; Failure, Liver
Conditions
Brief summary
A lot of different early and late complications may occur after liver transplantation. They could be related to surgical procedure, to infectious diseases or immuno-mediated diseases (acute cellular rejection, ACR). Almost all of those complications are characterized by an elevation in liver enzymes (ALT, AST and GGT) and a decline of liver function tests (serum bilirubin and INR increase) possibly leading to early allograft disfunction (EAD). In this scenario there is a lack of biomarker that could predict the development of ACR and/or EAD. The aim of this study is to explore the prognostic role of non-invasive instrumental and biological marker in the early post-transplant phase.
Interventions
None listed
Sponsors
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients eligible for liver transplantation following National and International Guidelines
Exclusion criteria
* No agreement or inability to give informed consent * Re-transplant patients * Liver transplant in fulminant hepatitis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Early Allograft dysfunction (EAD) | 2 weeks from Liver transplantation | Olthoff criteria: bilirubina≥ 10 mg/dL in 7th post-operative day, international normalized ratio (INR) ≥ 1.6 in 7th post-operative day 7; ALT or AST\> 2000 IU/L during the first 7 days after liver transplantation |
Countries
Italy
Contacts
Primary ContactLuca Miele, MD, PhD
Outcome results
None listed