Septic Arthritis
Conditions
Keywords
Septic Arthritis, diagnostic criteria
Brief summary
Septic arthritis (SA) is a rare but highly disabling disease. The ideal diagnosis criteria is not well established. There is an urgent need to establish golden standard for diagnosis.
Detailed description
Septic arthritis (SA) is a rare but highly disabling disease. Epidemiologic studies have documented an incidence of 0.9-1.3 per 100,000 \[1, 2\]. The treatment is challenging and the ideal diagnosis criteria is not well established. The specific tactics employed by relevant researches varied widely \[3-6\]. Patients with recurrent sepsis may require arthrodesis or amputation, which would result in severe functional loss \[2\]. Therefore, there is an urgent need to establish golden standard for diagnosis.
Interventions
DIAGNOSTIC_TESTHistory taking and physical examination
including fever, joint pain, local swelling and redness, sinus
DIAGNOSTIC_TESTbiopsy
including arthrocentesis culture，and frozen section
DIAGNOSTIC_TESTLaboratory test
including white blood cell count, C-reactive protein, erythrocyte sedimentation rate, percent of polymorphonuclear leukocytes, albumin, and globulin
Sponsors
Zhejiang Hospital
The First Affiliated Hospital of Zhejiang Chinese Medical University
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
CASE_CONTROL
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* admission to orthopaedics * complete data
Exclusion criteria
* Accompanied with fracture * Accompanied with other infections * Accompanied with immune system diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| WBC counts | preoperatively | white blood cell (WBC) counts |
| %PMN | preoperatively | percent of polymorphonuclear leukocytes (%PMN) |
| CRP | preoperatively | concentration of C-reactive protein (CRP) |
| ESR | preoperatively | erythrocyte sedimentation rate (ESR) |
| Albumin | preoperatively | concentration of albumin |
| Globulin | preoperatively | concentration of globulin |
| Body temperature | preoperatively | to check whether there has been a fever (\>37.2°C) previously or now by medical history consultation and physical examination |
| joint swelling and redness | preoperatively | to check whether there is joint swelling and redness by visual inspection and palpation |
| sinus tract | preoperatively | to check whether there is any sinus tract by visual inspection |
| positive X-ray findings | preoperatively | to determine whether there are positive X-ray findings, such as bone destruction, narrowing of the joint space, etc. |
| positive MR findings | preoperatively | to determine whether there are positive MR findings, such as joint effusion, cartilage damage, etc. |
| positive pathological findings | intraoperatively | determined by 5 or more neutrophils per high-power field on histopathologic examination |
| positive culture | preoperatively | determined by a bacterial growth when culture of blood or joint fluid in agarose |
Countries
China
Contacts
Primary ContactRongxin He, PhD
Outcome results
None listed