Colonic Neoplasms, Rectal Neoplasms
Conditions
Brief summary
The goal of this clinical trial is to quantify the effects of aerobic exercise training compared to attention control on intermuscular adipose tissue in colorectal cancer survivors.
Interventions
BEHAVIORALAerobic exercise
Moderate- to vigorous-intensity aerobic exercise
BEHAVIORALProgressive stretching
Statistic stretching of eight major muscle groups
Sponsors
National Cancer Institute (NCI)
AdventHealth Translational Research Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years * Histologically confirmed stage I, II, or III colon or rectal cancer * Completed surgical resection with curative intent * Completed other cancer-directed treatments * Engage in \<150 minutes per week of moderate- to vigorous-intensity structured endurance exercise * No planned major surgery during the study period * Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire * Ability to provide written informed consent * Provide written approval by a qualified healthcare professional * Willing to be randomized
Exclusion criteria
* Evidence of metastatic or recurrent colorectal cancer * Concurrently actively treated other (non-colorectal) cancer * Scheduled to receive other postoperative cancer-directed treatment(s) * Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks * Currently participating in another study with competing outcomes * Contraindications to magnetic resonance imaging * Any dietary condition or restriction that would limit tolerance of a mixed meal challenge * Any other cardiovascular, pulmonary, orthopedic, neurologic, psychiatric, or other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol * Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Whole-Body Intermuscular Adipose Tissue | up to Week 12 | Mean (kg) whole-body intermuscular adipose tissue quantified using magnetic resonance imaging. |
Countries
United States
Contacts
Primary ContactJustin C. Brown, Ph.D.
Outcome results
None listed