Invasive Group A Streptococcal Infection

French Pediatric Nationwide Observatory of Invasive Group A Streptococcal Infection (in Childen for 0 to 18 Ages)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05788861

Acronym

ISAI

Enrollment

100

Registered

2023-03-29

Start date

2022-09-01

Completion date

2026-09-01

Last updated

2024-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Medical Care, Medical Complications, Outcome, Fatal, Risk Factors, Sepsis Due to Streptococcus, Group A, Severe Infection, Strain, Therapy, Virulence Factors

Brief summary

This study is observational, retrospective and prospective study in pediatric patients hospitalized with invasive streptococcal A infection

Detailed description

The main of this study is to identify and record cases of invasive and severe infections due to Streptococcus pyogenes. In order to evaluate the incidence of severe forms of disease and the possible contributing factors, and to optimize their management. Admitted patients to intensive care or critical care units in reported via Santé Publique France may also be included in this study. Secondly, epidemiological, clinical, bacteriological data of all severe or not cases, of group A Streptococcal infections will be compiled to describe their characteristics, and try to explain this recrudescence as well as possible.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Days to 17 Years

Healthy volunteers

Inclusion criteria

* Age\<18 years * Documented invasive Group A Streptococcus infection (identification of GAS in a normally sterile site or from another site in case of toxin shock or necrotizing dermo-hypodermatitis)

Exclusion criteria

* Opposition of the patient or his/her legal representative

Design outcomes

Primary

Measure	Time frame	Description
Hospitalisation	1 year	How long patient was hospitalised during this infection
Treatments provided in intensive care unit	1 year	what treatments are used in intensive care unit to treat infection
Complications	1 year	what are the complications due to severe infection
Treatments used in routine care unit	1 year	which treatments are used in routine care unit to treat the infection
Risk factors	1 year	description of underlying conditions
Characterization of Group A Streptococcus strains	1 year	Characterization of Group A Streptococcus strains by the CNR
Death	1 year	Death Outcome during hospitalisation

Countries

France

Contacts

Primary ContactLevy Corinne

corinne.levy@activ-france.fr1 48 85 04 04

Backup ContactBechet Stephane

stephane.bechet@activ-france.fr1 48 85 96 68

Outcome results