Obesity
Conditions
Keywords
Low Glycemic Load Diet, Obesity
Brief summary
To examine how a low glycemic index diet (LGID) changes biochemical parameters, body measurements, and body image perception in obese individuals with insulin resistance. Obesity groups with insulin resistance who received a control diet (CD) and a LGID will be compared with each other in terms of biochemical parameters, body image perception and body measurements. In addition, each group will be compared with the start and end measurements over the same values.
Detailed description
The main purpose of this study is to determine the effect of LGID on body image perception, biochemical parameters and body measurements in obese individuals with insulin resistance. Sub-objectives of the study; Determination of the effect of LGID on fasting blood glucose, fasting insulin level and HOMA-IR levels compared to CD. Determination of the effect of LGID on body weight, fat mass, muscle mass, body muscle ratio and body mass index (BMI) compared to CD. Determination of the effect of LGID on body image perception status compared to CD.
Interventions
BEHAVIORALLow Glycemic Index Diet
1. Participants who came to the hospital for control and were interested in the study contacted the study researchers and eligibility was determined through face-to-face interviews. Potential participants were invited to a screening visit to verify eligibility. 2. The LGID program was initiated as an outpatient treatment in patients who applied to a dietitian. 3) Medium and high GI carbohydrates (GI \> 55) were excluded from the diet and only low GI (GI \< 50) foodstuffs were allowed. 4) A list of low glycemic index foods were given to the patients. In addition, a list of foods to avoid (medium and high glycemic index) is provided.
Sponsors
Uskudar University
Study design
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
NONE
Masking description
prospective, two-arm randomized-controlled trial, Researchers who have no knowledge about group allocation and study's objectives, will collected the post-intervention data.
Intervention model description
Different nutrition programs were applied to obese individuals divided into control and experimental groups. While the experimental group was given a healthy/balanced nutrition program containing carbohydrates and aimed to lose weight, a nutritional program that was balanced and aimed to lose weight but did not make any classification was applied to the control group. At the end of 8 weeks, biochemical parameters and scales were compared.
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* BMI above 24 kg/m2, or the either one (fat mass ≧ 30% or waistline \> 80 cm) * Can provide informed consent * Can be contacted by telephone * Waist circumference \> 90 cm for men and \> 80 cm for women
Exclusion criteria
* Pregnancy or lactation * Active or suspected chronic infection * Treatment affecting insulin sensitivity * A secondary disease state (Cardiovascular disease, cancer, psychiatric, etc.) * Any weight loss operation (gastric bypass, gastric balloon, etc.) * A special nutritional program (cancer, kidney disease, etc.) * Using any food supplement or medication known to affect whole body metabolism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Body fat ratio | Changes within and between groups are evaluated on the start and last day of the intervention (day 120). | Body fat ratio as assessed by bioelectrical impedance analysis -- whole body composition was evaluated. |
| Homeostatic Model Assessment for Insulin Resistance | Changes within and between groups are evaluated on the start and last day of the intervention (day 120). | Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index was obtained by the following formula: fasting glucose (mg/dl/18) x fasting insulin (U/mL)/22.5. A HOMA-IR index \>2.5 is in favor of Insulin Resistance (IR). |
| Cholesterol | Changes within and between groups are evaluated on the start and last day of the intervention (day 120). | Blood samples were collected after an overnight fast by using 10 mL plain tubes. Lipid profile was measured by using Cholesterol Kits and total cholesterol levels were measured using the sum of the LDL and HDL plus one-fifth of triglyceride levels. |
| Fasting plasma glucose | Changes within and between groups are evaluated on the start and last day of the intervention (day 120). | Fasting plasma glucose (FPG) levels were determined by taking a blood sample from participants who have fasted for at least 8 hours, Fasting glucose is between 75-95 mg/dL (4.2-5.3 mmol/L). |
| Fasting insulin level | Changes within and between groups are evaluated on the start and last day of the intervention (day 120). | Fasting insulin is between 18-48 pmol/L. |
| Body weight | Changes within and between groups are evaluated on the start and last day of the intervention (day 120). | Body weight was measured in kilograms. |
| Body muscle ratio | Changes within and between groups are evaluated on the start and last day of the intervention (day 120). | Body muscle ratio as assessed by bioelectrical impedance analysis -- whole body composition was evaluated. |
| Body muscle mass, kg | Changes within and between groups are evaluated on the start and last day of the intervention (day 120). | Body muscle mass as assessed by bioelectrical impedance analysis -- whole body composition was evaluated. |
| Body mass index | Changes within and between groups are evaluated on the start and last day of the intervention (day 120). | Body mass index (BMI)=weight/(height)\^2 |
| Body fat mass, kg | Changes within and between groups are evaluated on the start and last day of the intervention (day 120). | Body fat mass as assessed by bioelectrical impedance analysis -- whole body composition was evaluated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of body image scale | Changes within and between groups are evaluated on the start and last day of the intervention (day 120). | The body image scale (BIS) includes 10 items, and was developed to briefly and comprehensively assess the affective (e.g., feeling self-conscious), behavioral (e.g., difficulty in looking at the naked body), and cognitive (e.g., satisfaction with appearance) aspects of body image in patients. It is a 4-point scale (0 = not at all and 3 = very much), and the final score is the sum of scores for 10 items, ranging from 0 to 30, with a lower score representing a better body image. |
Countries
Turkey (Türkiye)
Outcome results
None listed