ERILs Und SNILs Unter SOC

Early Recurrent Ischemic Lesions (ERILs) and Silent Neurologic Ischemic Lesions (SNILs) in Diffusion-weighted Magnetic Resonance Imaging (DW-MRI) - a Pilot- Observational Study Under Standard of Care (SOC)

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05786170

Enrollment

Registered

2023-03-27

Start date

2019-09-30

Completion date

2021-07-05

Last updated

2023-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke, Acute

Brief summary

1. How many ERILs occur in caucasian patients with LAA stroke during 7 days on standard treatment? 2. How many SNILs occur between 7 and 30 days after acute ischemic event on standard treatment? 3. How many of during acute event diagnosed lesions (ERILs) are (still) detectable after 30 days? 4. Are there relevant risk faktors for the occurence of ERILs and SNILs (eg Diabetes or Biomarkers)?

Detailed description

In this trial, patients will be observed if they develop early recurrent ischemic lesions (= ERILs) or silent neurologic ischemic lesions (= SNILs) after acute stroke or transitoric ischemic attack (TIA) based on atherothrombosis (LAA-stroke) on standard therapy during 30 days (day 7 and day 30 after acute event) via DW-MRI (diffusion-weighted magnetic resonance imaging). We want to investigate if diffusion-weighted imaging of silent brain infarcts occuring during standard therapy is a suitable surrogate outcome measure for interventional studies

Interventions

DIAGNOSTIC_TESTdiffusion-weighted magnetic resonance imaging

diffusion-weighted magnetic resonance imaging

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* LAA stroke or TIA * ERILs or SNILs detected in initialDW-MRI * signed informed consent

Exclusion criteria

* planned surgical intervention * iv Thrombolysis * atrial fibrillation * contra indications against DW-MRI

Design outcomes

Primary

Measure	Time frame	Description
1. How many ERILs occur in caucasian patients with LAA stroke during 7 days on standard treatment?	7 days after acute stroke	DW-MRI to detect lesions

Secondary

Measure	Time frame	Description
2. How many SNILs occur between 7 and 30 days after acute ischemic event on standard treatment and how many of during acute event diagnosed lesions (ERILs) are (still) detectable after 30 days?	30 days after acute stroke	DW-MRI to detect lesions

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026