Vestibular Schwannoma Organoids

Vestibular Schwannoma Stem Cell Organoids

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05786144

Enrollment

100

Registered

2023-03-27

Start date

2020-06-01

Completion date

2026-01-01

Last updated

2026-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vestibular Schwannoma

Brief summary

In standard of care regularly planned surgery, tissue will be obtained from patients who are suspicious for having vestibular Schwannoma (on MRI). The tissue that remains after the pathologist gathered sufficient for analysis, the remaining tissue is used for creating tumour stem cell organoids.

Detailed description

This project constitutes scientific research since the presence of tumor stem cells has not been shown in schwannoma before. Secondly the organoid model has not yet been described for VSs. The correlation between effect in schwannoma organoids and in patients has to be evaluated but can proof to be very valuable since it has been shown in a number of tumors. The tumor tissue will be acquired during regularly planned surgery. The tissue that is used is what is left after sufficient material has been sent to the pathologist to make the diagnosis. So the tissue that is used is removed routinely during surgery, but instead of banking it at the pathology department, it is used for the research project. Blood samples that can be used to compare normal DNA to tumor cells DNA will be acquired from central lines that are routinely placed during these procedures, so no additional interventions will be done in acquiring the tissue and blood for this study.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* MRI with suspicion for vestibular schwannoma * Indication for surgery in the skull base committee * 18 years or older

Exclusion criteria

* Refusal to participate * Younger than 18 years * Incapacitated

Design outcomes

Primary

Measure	Time frame	Description
Feasibility	10 years	Feasibility to create organoids from schwannoma tumour tissue and make a "living" biobank of these tissues in the laboratory to study the resistance mechanisms towards treatments.

Secondary

Measure	Time frame	Description
Phenotype	10 years	Comparing the phenotypical profile of the vestibular schwannoma organoid to the phenotypical profile of the original tumour.
Genetic	10 years	Comparing the genetic profile of the vestibular schwannoma organoid to the genetic profile of the original tumour.
Epigenetic	10 years	Comparing the epigenetic profile of the vestibular schwannoma organoid to the epigenetic profile of the original tumour.
Proteomic	10 years	Comparing the proteomic profile of the vestibular schwannoma organoid to the proteomic profile of the original tumour.
Transcriptomic	10 years	Comparing the transcriptomic profile of the vestibular schwannoma organoid to the transcriptomic profile of the original tumour.

Countries

Netherlands

Contacts

PRINCIPAL_INVESTIGATORKoos Hovinga

Maastricht University Medical Center

PRINCIPAL_INVESTIGATORMarc Vooijs, MD, PhD

Maastro

Outcome results