Fetal Anomaly, Ultrasound
Conditions
Brief summary
The aim of this retrospective longitudinal study was to describe a key factor in the prenatal diagnosis of isolated cleft palate on the axial transverse view, in order to provide better understanding, detection and diagnosis of this anomaly.
Detailed description
Objective: The study aims to evaluate the role of the posterior hard palate angle in the prenatal diagnosis of cleft palate. Methods: Stored images of the axial transverse view of the fetal secondary palate, obtained at three-level ultrasounds, were used to evaluate the posterior border of the hard palate. The investigators studied the visualization of the posterior nasal spine and the presence of a gap within the hard palate. The investigators also assessed the posterior angle of the hard palate, formed by the posterior borders of the palatine bones next to the most posterior middle point of the palatine bone. The study population comprised 65 consecutive pregnancies of unaffected cases and 17 pregnancies with 24 assessments at different time points, suspected for a cleft palate without cleft lip, including 7 cases of cleft palate, 4 cases of high arched palate and 6 false positive cases.
Interventions
DIAGNOSTIC_TESTPosterior angle of the hard palate
Fetal ultrasound
Sponsors
Poitiers University Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Inclusion criteria
\- all patients suspected for a cleft palate without cleft lip referred to the Multidisciplinary Center for Prenatal Diagnosis in Poitiers (France) between January 2019 and January 2023.
Exclusion criteria
for the control group: * major congenital anomalies or chromosomal aberration, * premature rupture of the membranes, * fetal demise, * patients aged under 18 years. * If the available images did not allow the evaluation of the hard palate, the case was excluded from further consideration.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of cleft palate without cleft lip | derivery | Presence of cleft palate without cleft lip in postnatal exam |
Countries
France
Outcome results
None listed