Stomach Neoplasms
Conditions
Brief summary
In this study, the investigators evaluate the effect of total intravenous anesthesia using sufentanil-remimazolam and remifentanil-remimazolam on postoperative pain in patients undergoing laparoscopic gastrectomy.
Interventions
DRUGsufentanil-remimazolam group
Induction of general anesthesia with 6mg·kg-1·h-1 of remimazolam combined with 0.5 ng·ml-1 of sufentanil. Maintenance of general anesthesia with 1-2mg·kg-1·h-1 of remimazolam combined with 0.2 - 0.6 ng·ml-1 of sufentanil.
DRUGremifentanil-remimazolam group
Induction of general anesthesia with 6mg·kg-1·h-1 of remimazolam combined with 4 ng·ml-1 of remifentanil. Maintenance of general anesthesia with 1-2mg·kg-1·h-1 of remimazolam combined with 2-6 ng·ml-1 of remifentanil.
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. 20years or older 2. Scheduled for laparoscopic-assisted gastrectomy 3. American Society of Anesthesiologists(ASA) physical status I and III
Exclusion criteria
1. Emergency operation 2. Patients with a history of severe hypersensitivity reaction to dextran 40 3. Patients who cannot use patient controlled analgesia(PCA) 4. Patients with morbid obesity \[body mass index (BMI) \>35 kg/m2\] 5. Patients with history of uncontrolled hypertension (diastolic BP \>110mmHg) or DM 6. Patients with history of heart failure (unstable angina, congestive heart failure) 7. Patients with history of liver failure, renal failure, allergic to medicine 8. Patients with history of cerebrovascular disease (cerebral hemorrhage, cerebral ischemia) 9. Patients with history of uncontrolled psychiatric disease (PTSD, anxiety, depression) 10. Patients with obstructive sleep apnea 11. Patients who cannot read the consent form (examples: Illiterate, foreigner) 12. Patients who withdraw the consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total consumption of fentanyl in 24 hours after surgery | after 24 hours postoperative period | To investigate the effect of total intravenous anesthesia with intraoperative sufentanil-remimazolam and remifentanil-remimazolam on postoperative pain, total cumulative dose of fentanyl was measured for the first postoperative 24 hour. |
Countries
South Korea
Contacts
Primary ContactSun Joon Bai, MD, PhD
Outcome results
None listed