Bronchiectasis
Conditions
Brief summary
Effect of cardiovascular comorbidities on disease severity and quality of life in Patients with acute exacerbation of non-cystic fibrosis bronchiectasis
Detailed description
The study will include patients with bronchiectasis, and in an attempt to correlate the effect and burden of cardiovascular comorbidities in those patients, we will study the quality of life in those patients in comparison to the control group ( patients with bronchiectasis and without any other comorbidities) using SF-36 quality of life questionnaire. We will also study the inflammatory markers in both groups using D-dimer, BNP, and CRP and correlate them with the frequency of hospital admission, the severity of symptoms, and the general health state.
Interventions
DEVICEEchocardiography
echocardiographic study of both groups
Sponsors
Assiut University
Aliae AR Mohamed Hussein [ahussein
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
• Any Patients with Bronchiectasis had no comorbidities other than cardiovascular comorbidities during the study period.
Exclusion criteria
* Any Patients who refuse to participate in the study. * Any other comorbidity or end-organ failure may affect the study's result.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| assessment of BNP (Brain natriuretic peptide) pg/ml levels in patients with bronchiectasis and cardiovascular comorbidities. | March 2023 to September 2023 | Serum BNP (Brain natriuretic peptide) pg/ml will be compared in both groups. |
| Assessment of Quality of life in patients and control groups using The Short Form (36) Health Survey (SF-36) | March 2023 to September 2023 | The Short Form (36) Health Survey will be performed in both groups. The SF-36 consists of eight scaled scores, which are the weighted sums of the questions in their section. Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hospitalization frequency in patient group compared to control group. | March 2023 to September 2023 | Number of hospital admission in the last year will be compared in both groups. |
Countries
Egypt
Contacts
CONTACTShaadad Shaddad, MD
CONTACTAhmad Shaddad, MD
PRINCIPAL_INVESTIGATORAhmad Shaddad
Assuit University Faculty of Medicine
Outcome results
None listed