Connective Tissue Graft From Tuberosity Area and L-PRF Associated With Coronally Advanced Flap for Root Coverage

Comparative Evaluation of the Coronally Advanced Flap (CAF) Using a Connective Tissue Graft From the Tuberosity (tCTG) or L-PRF Membranes: a Randomized Controlled Clinical Trial.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05783258

Enrollment

Registered

2023-03-24

Start date

2022-06-13

Completion date

2023-10-29

Last updated

2023-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival Recession

Keywords

Root coverage, Periodontal plastic surgery

Brief summary

The aim of the present randomized controlled clinical study is to compare the efficacy of subepithelial connective tissue graft harvested from the maxillary retromolar tubeosity area and L-PRF membranes in the treatment of RT1 recessions by coronally advanced flap. A total of 30 patients will be recruited and randomly assigned to the test group treated with CAF+tSCTG or the control group treated with (CAF+L-PRF). For each experimental site the parameters of gingival recession (GR), pocket depth (PD), clinical attachment level (CAL), keratinized gingiva width (KT) and gingival thickness (GT) will be analyzed at baseline (T0) and at 12 months after the surgical procedure (T1). In addition, was also evaluated the different morbidity of the two surgical techniques, using the VAS scale values recorded in the first 2 weeks following surgery. It was checked the Patient Related Esthetic Score and Dentine hypersensivite reduction.

Interventions

PROCEDUREPeriodontal surgery with CAF+tSCTG

Coronally advanced flap and subepithelial connective tissue graft harvested from the maxillary tuberosity area.

PROCEDUREPeriodontal surgery with CAF+L-PRF

Coronally advanced flap and L-PRF membranes

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Presence of a class RT1 recession; * age \> 18 years; * systemic health conditions that do not affect the periodontium; * Non smoker; * FMPS and FMBS values \< 20% before the surgical procedure; * absence of implants or subgingival restorations in the sites to be treated; * presence of adequate tissue distal to the last maxillary molar.

Design outcomes

Primary

Measure	Time frame	Description
Gingival thickness	12 months	Gingival tissue thickness 2 mm apical to the recession

Secondary

Measure	Time frame	Description
Keratinized tissue height	12 months	Distance between gingival margin and Mucogingival Junction
Gingival recession	12 months	Distance from cementoenamel junction and gingival margin
Complete root coverage	12 months	Percentage of experimental sites that achieved complete root surface coverage.
Clinical attachment level	12 months	Distance between cementoenamel junction(CEJ) and depth of the pocket
Pocket depth	12 months	Distance between gingival margin and bottom of the pocket

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026