Stress
Conditions
Keywords
L-Tyrosine supplementation, Perioperative stress
Brief summary
Patient undergoing surgery is exposed to many stressors: diachronic (gesture anticipation), synchronic (intraoperative aggression) and historical (subject's personality). Reducing the level of stress experienced is a factor for improving the quality of the surgical gesture and the simplicity of the follow-up. The previous methods used were intended to reduce the body's reactivity to aggressions through anaesthesia consultation and L-Tyrosine supplementation. Currently with the progression of outpatient surgery and the need for early rehabilitation, L-Tyrosine supplementation is suppressed to improve recovery. Some patients, however, have a high level of stress that may require anxiolysis when the ideal treatment does not exist (ineffective hydroxyzine, benzodiazepines having many side effects). The strategy of this work is to improve the body's ability to respond to stressors, by administering l-tyrosine with no impact on waking or returning home.
Interventions
DIETARY_SUPPLEMENTL-tyrosine supplementation
L-Tyrosine supplementation before surgery for inguinal hernia under general anaesthesia
DIETARY_SUPPLEMENTPlacebo supplementation
Placebo supplementation before surgery for inguinal hernia under general anaesthesia
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Intervention model description
prospective, monocentric, double-blind randomized study
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Membership of a social security scheme or equivalent * At least 18 years of age * Able to express consent * Indication of unilateral or bilateral inguinal hernia cure * General anaesthesia proposed and retained for inguinal hernia treatment regardless of surgical technique
Exclusion criteria
* Surgical indication for another reason or hernial cure associated with another procedure * Smoking estimated at more than 35 pack-years * History of psychiatric pathology * ASA 3 or 4 according to the American Society of Anesthesiologists classification. As a reminder, an ASA 3 class concerns a patient with a severe but not disabling general disease, and an ASA 4 class concerns a patient with a disabling general disease involving the vital prognosis. * ASA 2 and having at least one of the following pathologies or patients treated with -blockers: insulin-dependent diabetes, high blood pressure, heart rhythm disorder, dysthyroidism, progressive neurological disease, long-term benzodiazepines. * Starch allergy or intolerance
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Variation of anxiety status | between the day before surgery and thes day after surgery | Anxiety score measured using Y-A STAI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Other stress markers variation | the day before surgery | anxiety visual analogue scale (from 0 to 10, 10 is worst) |
Countries
Monaco
Contacts
Primary ContactBertrand PRUNET, PU-PH
Backup ContactNicolas RIJO
Outcome results
None listed