Life Quality, Hospital Mortality
Conditions
Brief summary
Sepsis is a syndrome of life-threatening organ dysfunction caused by a dysregulated host response to infection.Acute catabolic response in critically ill patients struck by sepsis, manifested by massive protein breakdown in a short time.This pathology frequently leads to prolonged hospitalization and mechanical ventilation, increased mortality, and reduced quality of survival.It is uncertainty whether sepsis patients in ICU can benefit from high protein intake combined with early exercise. Even though the combination has been shown to be beneficial in other populations.In the present study, the investigator will evaluate the effects of a combination of high protein targets combined with early rehabilitation in sepsis patients in ICU.
Detailed description
Existing research results confirm that high target protein support can reduce the mortality of sepsis patients. Early bedside rehabilitation has a good effect on cognitive function after ICU. This study combined high-protein nutritional support with bedside rehabilitation to improve the quality of life in patients with sepsis after ICU.
Interventions
DIETARY_SUPPLEMENThigh protein
Patients in high-protein group will be given a target protein amount of 2.0 g/kg/d. Standard enteral nutrition is the first choice,the remaining target value will be met by intravenous amino acid infusion.
BEHAVIORALrehabilitation
In this trial, the investigator will provide early rehabilitation treatment such as respiratory training, bicycle training, and medium frequency electrical stimulation to patients.
DIETARY_SUPPLEMENTstandard protein
The investigator set a protein target of 1.2 g/Kg/d for the standard protein group, which will be supplied enterally or parenterally.
Sponsors
The First Affiliated Hospital of Soochow University
Jinling Hospital, China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Inclusion Standard 1. Patients with sepsis 2. Patients aged 18-70 years 3. Time of admission ≤48 h 4. Non-terminal condition Exclusion Standard 1. Severe acute kidney injury 2. Severe chronic liver disease (MELD score ≥20) or acute hepatic failure 3. Protein allergy 4. Pregnancy and lactation 5. BMI≥30 kg/m²
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hospital Mortality | Day 90 | Chart review |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Nutrition related indicators | Hospital discharge | Chart review |
| Physical functioning | Hospital discharge | Grip dynamometer |
| Prognostic factor | Hospital discharge | Chart review |
| Health-related quality of life | Day 90 | SF-36 and EQ-5D-5L |
Outcome results
None listed