Family Genetic Characteristics of Osteoporosis
Conditions
Keywords
Osteoporosis families, Kidney-yang deficiency, Genetic correlation of disease, Bone density
Brief summary
Bone metabolism and genetic characteristics of osteoporosis pedigree with kidney-yang deficiency
Detailed description
Families with or without osteoporosis of kidney-yang deficiency type will be included and compared with each other. Their genetic characteristics, bone changes, and TCM constitution are the focus of research.
Interventions
None listed
Sponsors
Shanghai University of Traditional Chinese Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Be able to cooperate with inspection.There is blood relationship between the members of the enrolled family.
Exclusion criteria
* Unable to cooperate with inspection.There is not blood relationship between the members of the enrolled family.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in bone mineral density from baseline to 5 years after enrollment | at enrollment | lumbar (L1-4 as well as total) and hip bone mineral density will be recorded by dual energy X-ray absorptiometry |
| Physical phenotype of traditional Chinese medicine | at enrollment | Occurrence of kidney yang deficiency |
| Understand the general situation through the questionnaire | at enrollment | Including age（year）, sex（man,wowan）, height(cm), weight(kg), menstrual period,history of smoking and drinking, living habits, fracture history and risk assessment, skeletal muscle assessment, living environment, Chinese medicine constitution, etc |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 25(OH) vitamin D | at enrollment | serum total 25(OH) vitamin D |
| Procollagen type I N-terminal propeptide | 5 years after enrollment | serum procollagen type I N-terminal propeptide (PINP) |
| Osteocalcin | at enrollment | serum osteocalcin |
| procollagen type I N-terminal propeptide | at enrollment | serum procollagen type I N-terminal propeptide (PINP) |
| Bone alkaline phosphatase | at enrollment | serum bone alkaline phosphatase (BALP) |
| β-crosslaps | at enrollment | serum β-crosslaps (β-CTX) |
| Ca | at enrollment | serum Ca |
| P | at enrollment | serum P |
| Mg | at enrollment | serum Mg |
| Fibroblast growth factor | at enrollment | serum fibroblast growth factor (FGF)23 |
| Parathormone | at enrollment | serum parathormone (PTH) |
| Gene testing(BGIseq T5,WGS) | at enrollment | Carry out whole-gene testing on the samples with obvious family heritability of osteoporosis, and analyze the differences at the gene level through sequencing compared with the control group |
Countries
China
Contacts
Primary ContactYongjun Wang
Outcome results
None listed