Study of Different Gating Techniques for PET Image of Lung and Liver Lesions

Study of Different Gating Techniques of Positron Emission Tomography Acquisition Focus on Lung or Liver Nodules. Comparaison on Phantoms and a Series of Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05779865

Acronym

PETGATQUANT

Enrollment

Registered

2023-03-22

Start date

2023-02-15

Completion date

2023-09-21

Last updated

2023-09-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Metastases, Lung; Nodule

Keywords

positron emission tomography, nodule uptake, gating, quantification

Brief summary

Lesions blurred by respiratory motion are common in fluorine-18 PET/CT studies. To avoid these artefacts, several standard gating correction technics are available. the investigator aimed to compare the impact of different gating techniques based on phase, amplitude, elastic-motion monitored with and without pressurre sensor device on standardized uptake value (SUVmax and SUVpeak) and uptake volume (UV) measurements on different sizes of pulmonary and liver lesions. The feasability of this study will be done using anthropomorphic coupled with a motion phantom and on a series of patients.

Detailed description

PET-CT images will be acquired on a Biograph Vision600 PET/CT, fitted with 26cm axial field of view and time of flight. Phantom study will use an anthropomorphic TORSO phantom with a programmable motion phantom, mimicking respiratory motion (QUASAR). Spheres with various internal diameters will be introduce into the lungs (air density) adding an axial mechanical device simulating breathing movement of +/-20mm. Concentration in the spheres will be the same for all diameters. The background and liver activities will be approximatively respectively 38 and 14 MBq. This phantom will be a simulating patient only for lung lesions. The investigator will compare 6 different PET acquisitions: standard 3min acquisition without movement as our reference of trues SUVmax and UV, 3min acquisition with simulated breathing movement without any gating and 3min with respectively gating techniques based on phase, amplitude, elastic-motion monitored with and without pressurre sensor device. Patient study will be on 50 consecutive patients with lung or liver nodules. 18F-FDG injection will be around 2.5 MBq/kg. The investigator will compare 5 different PET acquisitions: standard acquisition with free respiratory movement as our reference of trues SUVmax and UV, acquisitions with respectively gating techniques based on phase, amplitude, elastic-motion monitored with and without pressurre sensor device.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* presence at least of one hepatic or lung nodule

Exclusion criteria

* none

Design outcomes

Primary

Measure	Time frame	Description
Comparison of the different gating systems in lung lesions visualization	Inclusion	Classification, based on a phantom and patients studies, of the different gating system in view of the volume and SUV (max and peak) modification for lung lesions

Secondary

Measure	Time frame	Description
Comparison of the different gating systems in liver lesions visualization	Inclusion	Classification, based on a patients studies, of the different gating system in view of the volume and SUV (max and peak) modification for liver lesions

Countries

Monaco

Outcome results