Healthy
Conditions
Brief summary
The aim of this study is to investigate Lepidium meyenii (Maca) extract supplementation on exercise-induced responses of the biochemical, and physiological parameters.
Detailed description
Thirty healthy male participants were divided into Maca group (2.25 g of Maca extract, twice per day for 12 weeks) and placebo group (n = 15). All participants conducted a graded exercise test on treadmill to determine the maximal oxygen consumption (VO2max) before and after supplementation, and the speed equivalent to 70% VO2max was conducted for an exhaustive endurance exercise test by treadmill for 1 hours, followed by 90% VO2max until exhaustion.The time to exhaustion, peak oxygen consumption, maximal heart rate and average heart rate will be recorded during the exercise period. Venous blood samples will be drawn before, immediately after, 2-hour after, 4-hour after, and 24-hour after the exhaustive endurance exercise test. Data was analyzed by Two-way mixed design ANOVA.
Interventions
DIETARY_SUPPLEMENTmaca
2.25 g of Maca extract, twice per day for 12 weeks
DIETARY_SUPPLEMENTplacebo
2.25 g of starch, twice per day for 12 weeks
Sponsors
Panion & BF Biotech Inc.
Taipei Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
A double-blind, matched-pair study design
Eligibility
Sex/Gender
MALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
\- The volunteers included have conditions as stated below : 1. male adult whose no history of cardiovascular, liver, kidney and diabetes disease 2. no acute sport injury 3. did not participated in any clinical trials or research in the last 3 months before our experiment 4. no supplements were taken during the experimental period 5. were requested to maintain their regular daily life style and avoid alcohol intake
Exclusion criteria
\- The volunteers were excluded if they have the situation stated below: 1. history of cardiovascular, liver, kidney and diabetes disease 2. acute sport injury 3. participated in any clinical trials or experimental research in the last 3 months before our experiment 4. taking supplement during the experimental period 5. did not maintain their regular eating habit or drink alcohol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of CD4+ | before exercise |
| Concentration of CD8+ | before exercise |
| Concentration of CD19+ | before exercise |
| Concentration of CD56+ | before after exercise |
| Concentration of leukocyte | before exercise |
| Concentration of neutrophil | before exercise |
| Concentration of lymphocyte | beore exercise |
| Concentration of GSH | before exercise |
| IConcentration of GSSG | before exercise |
| Concentration of GSSG | immediately after exercise |
| Concentration of CK-MB | before exercise |
| Concentration of TNF-α | before exercise |
| Concentration of IL-1β | before exercise |
| Concentration of IFN-γ | before exercise |
| Concentration of IL-2 | before exercise |
| Concentration of IL-4 | before exercise |
| Concentration of IL-8 | before exercise |
| Concentration of IL-10 | before exercise |
| Concentration of TBARS | before exercise |
| Concentration of PC | before exercise |
| Concentration of SOD | before exercise |
| Concentration of catalase | before exercise |
| Concentration of GPx | before exercise |
| Concentration of CK | before exercise |
| Concentration of LDH | before exercise |
| Concentration of IL-6 | before exercise |
| Concentration of cTnI | before exercise |
| Concentration of NT proBNP | before exercise |
| Concentration of testosterone | before exercise |
| Concentration of LH | before exercise |
| Concentration of FSH | before exercise |
| Concentration of NO | before exercise |
| Concentration of GOT | before exercise |
| Concentration of GPT | before exercise |
| Concentration of BUN | before exercise |
| Concentration of creatinine | before exercise |
Countries
Taiwan
Outcome results
None listed