Skin Pigmentation, Wrinkle
Conditions
Keywords
Vitamin C, Acetyl Zingerone
Brief summary
The purpose of this study is to asses the impact of topically applying a form of vitamin C known as tetrahexyldecyl Ascorbate (THDA) along with a novel anti-aging ingredient, acetyl zingerone, compared against applying THDA alone.
Detailed description
In this study, we examine the effects of adding acetyl zingerone to vitamin-C derived ester THDA on its effects on the signs of photoaging (redness, uneven skin tone, and the appearance of fine lines) and compare it to the effects of applying THDA alone. Acetyl zingerone is derived from ginger and has anti-oxidant properties In this study, participants will be randomized to either receiving a THDA + acetyl zingerone product or a THDA only product. This means that you will have an equal chance of receiving either product. You and the research team will not know which product you have been randomized to received because the products will be labelled with a code. The research team will only know which product contained THDA + acetyl zingerone and which product contained only THDA at the end of the study.
Interventions
OTHERTHDA + Acetyl Zingerone Topical Product
A skin care product with Acetyl Zingerone (Synoxyl® AZ) and THDA (VitaSynol® C) used twice daily
OTHERTHDA
A skin care product with THDA (VitaSynol® C) used twice daily
Sponsors
Sytheon Ltd.
Integrative Skin Science and Research
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and women between the ages of 30 years old and 65 years old.
Exclusion criteria
* Individuals who are pregnant or breastfeeding. * Prisoners. * Adults unable to consent. * Individuals who have changed any of their hormonal based contraception within 3 months prior to joining the study. * Subjects using any topical retinoid, acetyl zingerone, vitamin C, bakuchiol, hyaluronic acid or benzoyl peroxide containing topical product within 2 weeks of starting study or any subject unwilling to refrain from washout prior to enrollment. * Subjects with any of the following facial cosmetic treatments in the past 3 months or those who are unwilling to withhold the following facial cosmetic treatments during study including botulinum toxin, injectable fillers, microdermabrasion, intense pulsed light (IPL), peels, laser treatments, acid treatments, facial plastic surgery, or any other medical treatment administered by a physician or skin care professional which is designed to improve the appearance of facial skin. * Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Facial fine lines and wrinkles | 8 weeks | Change in severity of fine lines and wrinkles measured by photographic analysis (BTBP 3D Camera System) |
| Facial skin pigment evenness | 8 weeks | Change in the appearance of facial skin pigment intensity measured by photographic analysis (BTBP 3D Camera System) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Skin redness | 4 weeks | Change in the appearance of skin redness measured by photographic analysis (BTBP 3D Camera System) |
| Change in skin pigmentation in the undereye area | 4 weeks | hange in skin pigmentation in the undereye area by Skin colorimetric analysis of pigment |
| Facial fine lines and wrinkles | 4 weeks | Change in severity of fine lines and wrinkles measured by photographic analysis (BTBP 3D Camera System) |
| Tolerability of product | 4 weeks | Questionnaire based self-assessment about the tolerability of the topical skin product |
| Self-perception of skin parameters | 4 weeks | Survey based self-assessment of facial features such as fine lines and wrinkles, skin smoothness, skin firmness |
| Facial skin pigment evenness | 4 weeks | Change in the appearance of facial skin pigment intensity measured by photographic analysis (BTBP 3D Camera System) |
Countries
United States
Outcome results
None listed