Acute Ischemic Stroke
Conditions
Keywords
acute ischemic stroke, large vessel occlusion, medium vessel occlusion, real-world registry
Brief summary
This study is designed to observe the treatment options in real-world clinical practice as well as the safety and efficacy of different treatment strategies.
Detailed description
LOMEVO is a prospective, multicenter, real-world registry lasting for 10 years. A total of 50000 patients with large- or medium-vessel occlusion will be enrolled at approximately 30 centers around China.
Interventions
OTHERVisit at D90
Visits at 90±7 days after stroke onset were conducted by trained and blinded investigators, with face-to-face, telephone call or Internet access.
Sponsors
Xuanwu Hospital, Beijing
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* The clinical diagnosis is acute ischemic stroke with large- or medium- vessel occlusion (the criteria followed the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018) * Informed consent from the patient or surrogate
Exclusion criteria
* No additional
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| modified Rankin Scale (mRS) score | 90±7 days | Ordinal distribution of mRS at 90±7 days; modified Rankin scale (range, 0 to 6, with a score of 0 indicating no disability, 1 no clinically significant disability, 2 slight disability, 3 moderate disability but remaining able to walk unassisted, 4 moderately severe disability, 5 severe disability, and 6 death) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of National Institutes of Health Stroke Scale (NIHSS) | 24 hours | Change of National Institutes of Health Stroke Scale (NIHSS, a scale between 0 and 42 on which higher scores indicate more severe neurologic deficits) from baseline to 24 hours. |
| Door-to-Needle Time (DNT) | 24 hours | Time from the arrival of stroke patient in emergency to initiation of thrombolysis therapy. |
| Door-to-Puncture Time (DPT) | 24 hours | Time from the arrival of stroke patient in emergency to groin puncture. |
| Onset-to-recanalization time | 24 hours | Time from symptom onset to the beginning of recanalization (recanalization defined as expanded TICI scale≥2b). |
| Door-to-Recanalization Time (DRT) | 24 hours | Time from the arrival of stroke patient in emergency to the beginning of recanalization (recanalization defined as expanded TICI scale≥2b). |
| Puncture-to-recanalization time | 24 hours | Time from groin puncture to recanalization (recanalization defined as expanded TICI scale≥2b). |
| Excellent functional outcome | 90±7 days | Proportion of subjects with mRS 0-1 at 90±7 days. |
| Good functional outcome | 90±7 days | Proportion of subjects with mRS 0-2 at 90±7 days. |
| mRS 0-3 | 90±7 days | Proportion of subjects with mRS 0-3 at 90±7 days. |
| Symptom-to-thrombolysis time (STT) | 24 hours | Time from onset of symptoms to thrombolytic therapy. |
Other
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality | 90±7 days | All-cause mortality at 90±7 days |
| Complications related to intravenous thrombolysis | up to 7 days | Complications related to intravenous thrombolysis during hospitalization |
| Complications related to endovascular treatment | up to 7 days | Complications related to intravenous thrombolysis during hospitalization |
| Incidence of any intracranial hemorrhage | 36 hours | Incidence of any intracranial hemorrhage (Heidelberg criteria) measured at 36 hours |
| Incidence of clinically significant intracranial hemorrhage | 36 hours | Incidence of sICH (Heidelberg criteria) measured at 36 hours |
Countries
China
Contacts
Primary ContactJunwei Hao, MD; PhD
Backup ContactGaoting Ma, MD
Outcome results
None listed