Wrinkle
Conditions
Keywords
anti-aging, skin care
Brief summary
This study is to analyze and compare the effects of applying two topical vitamin-A derived ingredients on facial skin health, appearance and tolerability. One of these ingredients is retinol, and the other is Adapinoid, also known as Oleyl Adapalenate, a novel anti-aging ingredient.
Detailed description
We want to assess the effect of applying vitamin A-derived ingredients on facial skin health, appearance, and tolerability. One of these ingredients is retinol, and the other is Adapinoid, also known as Oleyl Adapalenate. In this study, participants will be randomized to either receiving a retinol product, or an Adapinoid product and they will be assessed at three follow up visits at week 4, week 8, and week 12.
Interventions
OTHERRetinol
Topical retinol (0.5%) applied to the face
OTHERAdapinoid
Topical Adapinoid (0.5%) applied to the face
Sponsors
Actera (Sponsor)
Integrative Skin Science and Research
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
35 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and women between the ages of 35 years old and 65 years old
Exclusion criteria
* Individuals who are pregnant or breastfeeding. * Prisoners. * Adults unable to consent. * Individuals who have changed any of their hormonal based contraception within 3 months prior to joining the study. * Subjects using any topical retinoid, acetyl zingerone, vitamin C, bakuchiol, hyaluronic acid or benzoyl peroxide containing topical product within 2 weeks of starting study or any subject unwilling to refrain from washout prior to enrollment. * Subjects with any of the following facial cosmetic treatments in the past 3 months or those who are unwilling to withhold the following facial cosmetic treatments during study including botulinum toxin, injectable fillers, microdermabrasion, intense pulsed light (IPL), peels, laser treatments, acid treatments, facial plastic surgery, or any other medical treatment administered by a physician or skin care professional which is designed to improve the appearance of facial skin. * Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Facial fine lines and wrinkles | 12 weeks | Change in severity of fine lines and wrinkles measured by photographic analysis (BTBP 3D Camera System) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Facial fine lines and wrinkles | 4 weeks | Change in severity of fine lines and wrinkles measured by photographic analysis (BTBP 3D Camera System) |
| Skin redness | 4 weeks | Change in the appearance of skin redness measured by photographic analysis (BTBP 3D Camera System) |
| Facial skin pigment evenness | 4 weeks | Change in the appearance of facial skin pigment intensity measured by photographic analysis (BTBP 3D Camera System) |
| Self-perception of skin health and appearance | 4 weeks | Survey-based self-assessment of aspects of skin health and appearance |
| Tolerability of product | 4 weeks | Questionnaire based self-assessment about the tolerability of the topical skin product |
Countries
United States
Outcome results
None listed