Effect of Dexmedetomidine on Left Ventricular Function in Coronary Artery Bypass Graft Surgery Outcome

Effect of Dexmedetomidine on Stress-induced Changes in Hemodynamics and Left Ventricular Function in Coronary Artery Bypass Graft Surgery Outcome

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05778305

Acronym

CABAG

Enrollment

Registered

2023-03-21

Start date

2023-01-29

Completion date

2023-12-31

Last updated

2024-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effect of Drug in CABAG Patients

Brief summary

50 patients of both sexes undergoing elective CABG surgery will be randomly divided into 2 groups, study group (Dex) group and control group (C) to determine the effect of dexmedetomidine on the peri-operative hemodynamic changes during CABG surgery.

Detailed description

The effect of dexmedetomidine during CABG surgery is studied regarding Ventricular function, pre bypass and post bypass using the transoeophageal echo (TEE), post-operative by transthoracic echocardiography (TTE) on day of surgery and after extubation. Incidence of intraoperative and post operative ischemia and arrhythmias using Electrocardiogram (ECG) as well as the length of ICU and hospital stay.

Interventions

DRUGDexmedetomidine

a central sympatholytic drug

OTHERnormal saline

saline is given to control group

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

30 Years to 60 Years

Healthy volunteers

Inclusion criteria

* undergoing elective CABG surgery

Exclusion criteria

* Patient refusal * Dementia patients * Poor ventricular function with ejection fraction below 40% * Asthmatic patients * Uncontrolled diabetic patients with HbA1c above 8 * Combined surgeries (CABG+ valves) * Emergency surgeries. * Pre-existing arrhythmia * Patients with renal impairment * Patients with hepatic impairment * Patients with heart block * Off-pump CABG

Design outcomes

Primary

Measure	Time frame	Description
Intra-operative ventricular function.	Intraoperative	global systolic function Ejection Fraction by TEE intraoperative
post-operative ventricular function.	Up to 24 hours postoperative	global systolic function Ejection Fraction by TTE postoperative

Secondary

Measure	Time frame	Description
hemodynamics	Immediate postoperative and up to 24 hours postoperative	Heart Rate (beat/minute),

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026