Critical Illness
Conditions
Keywords
VV ECMO, EIT, Lung perfusion
Brief summary
The purpose of this study is to investigate the feasibility of using electric impedance tomography (EIT) to monitor lung perfusion during veno-venous (VV) extracopreal membrane oxygenation (ECMO) support, as well as the effect of different ECMO flows on lung perfusion monitored by EIT.
Detailed description
This is a monocentric obsevensional study that uses EIT to monitor lung perfusion during VV ECMO support and the effect of different ECMO flows on lung perfusion as measured by EIT. Patients on VV ECMO who meet the withdrawal criteria as determined by clinical experts will have their ECMO flow gradually reduced. EIT lung ventilation and perfusion monitoring were performed at various ECMO flows.
Interventions
None listed
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. Patients aged ≥ 18 and ≤ 70 years； 2. Patients supported with VV ECMO for respiratory failure； 3. Patients are intubated and mechanically ventilated.
Exclusion criteria
1. EIT contraindications such as chest wound dressing, pacemaker installation, defibrillator, etc; 2. Patients who did not sign the informed consent form; 3. Pulmonary embolism; 4. Pneumothorax; 5. Medium to plenty of chest water; 6. Atrial fibrillation or other malignant arrhythmia leads to a decrease in cardiac output; 7. Refractory shock; 8. Severe chronic heart and lung disease has existed in the past; 9. BMI\>35 kg/m2; 10. Intra-abdominal pressure \>20mmHg.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lung perfusion at different VV ECMO flows | up to 24hour | Effect of Different VV ECMO Flows (ECMO flow at 4.5L,3.5L,2.5L,1.5L, and after ECMO withdrawal) on lung perfusion distribution Monitored by EIT |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lung ventilation at different VV ECMO flows | up to 24hour | Effect of Different VV ECMO Flows (ECMO flow at 4.5L,3.5L,2.5L,1.5L, and after ECMO withdrawal) on lung ventilation distribution monitored by EIT |
| Lung deadspace region at different VV ECMO flows | up to 24hour | Effect of Different VV ECMO Flows (ECMO flow at 4.5L,3.5L,2.5L,1.5L, and after ECMO withdrawal) on lung deadspace region monitored by EIT |
| Lung shunt region at different VV ECMO flows | up to 24hour | Effect of Different VV ECMO Flows (ECMO flow at 4.5L,3.5L,2.5L,1.5L, and after ECMO withdrawal) on lung shunt region monitored by EIT |
| Lung ventilation/perfusion matching at different VV ECMO flows | up to 24hour | Effect of Different VV ECMO Flows (ECMO flow at 4.5L,3.5L,2.5L,1.5L, and after ECMO withdrawal) on lung ventilation/perfusion matching monitored by EIT |
| Recirculation at different VV ECMO flows | up to 24hour | Recirculation at different VV ECMO flows (ECMO flow at 4.5L,3.5L,2.5L,and1.5L) |
Countries
China
Contacts
Primary ContactXiaobo Yang, prof.
Backup ContactYou Shang, prof.
Outcome results
None listed