Cluster-Randomized Trial of Air Filtration and Ventilation to Reduce Covid19 Spread in Homes

A Cluster-randomized Controlled Trial of Air Filtration and Ventilation Improvements to Reduce SARS CoV 2 Transmission Among Household Contacts

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05777720

Enrollment

214

Registered

2023-03-21

Start date

2023-01-30

Completion date

2025-12-30

Last updated

2026-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid19

Keywords

ventilation, air filtration, Covid19, SARS CoV 2, household transmission

Brief summary

Investigators are evaluating whether an intervention consisting of box-fans with MERV 16 filters ("filtration fans") and recommendations for improving ventilation in the home can reduce secondary spread of Covid19 from an index case to susceptible contacts within the home.

Interventions

DEVICEFiltration Fan

Investigators are using box fans with attached MERV16 filters, a design that has been tested and published in the scientific literature.

BEHAVIORALSafe-home pamphlet

The pamphlet has information on how the filtration fans work through visual images; and images of ventilation improvements in the home through opening windows.

BEHAVIORALMid-week phone call

On day 3-4 of the study, the study coordinator assigned to the house will call and check in regarding the filtration fan usage and remind families about the importance of filtration and ventilation.

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Household members live in a shared space (apartment, home) with others (as opposed to renting single rooms in a shared space, for example) * At least 3 other people live in the household aside from index case

Exclusion criteria

* If index case test positive day was over 2 days prior * If half or more household members are thought to be infected already * If household has fewer than 3 contacts interested in participating in the study * If fewer than 3 contacts are expected to be present in the house for a majority of the following 7 days

Design outcomes

Primary

Measure	Time frame	Description
Incidence of Covid19	7th day since enrollment in the trial	Investigators will measure the incidence of Covid19 in susceptible contacts on day 7.

Secondary

Measure	Time frame	Description
Incidence of new upper respiratory symptoms	7th day since enrollment in the trial	Investigators will measure reported new upper respiratory symptoms in susceptible contacts.
Average CO2 levels	7 days	Investigators will measure 7 day average CO2 levels in the home (measured in parts per million)

Countries

United States

Contacts

STUDY_DIRECTORYvonne Maldonado, MD

Stanford University

PRINCIPAL_INVESTIGATORAbraar Karan, MD