Focus: Nutritional Deficiency
Conditions
Brief summary
This study aims to find an easy urinary collection method for the assessment of urinary markers of micronutrient status.
Detailed description
Urinary collection in newborns and infants can be difficult. Our study aims to find an easy and cheap alternative to urinary collection bags and specialized pads that can be used to measure biomarkers of iodine and vitamin B12 status in urine and can be employed in large scale trials. Using correlation analyses, the association of urinary iodine and methylmalonic acid from healthy volunteers will be assessed between untreated sample and a sample expressed from a sanitary napkin. Participants will be recruited based on their dietary pattern (omnivorous, vegetarian and vegans) to have a broad spectrum of analyte concentration. Participants weight, height, age, nutritional supplement use and diet will be assessed.
Interventions
DIAGNOSTIC_TESTUrine collection and assessment of dietary intake by food frequency questionaire
urinary iodine, creatinine and methylmalonic acid, iodine and vitamin B12 dietary intake from foods and supplements
Sponsors
University of Hohenheim
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy volunteers Written informed consent
Exclusion criteria
BMI \< 18,5 and \>24,9 Use of medication (except contraceptives) Smoking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation untreated and expressed urine | 8-9 weeks after completion | Correlation of creatinine, methylmalonic acid and iodine between unprocessed urine and urine expressed from a sanitary diaper to evaluate possible matrix effects on analytes. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of urinary biomarkers with food and supplement intake | 8-9 weeks after completion | Correlation of dietary intake assessed by a food frequency questionnaire with urinary iodine and methylmalonic acid normalized to creatinine. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Mean difference of urinary biomarkers between groups | 8-9 weeks after completion | Exploratory analysis of differences by dietary group in urinary iodine nomalized to creatinin. |
Countries
Germany
Outcome results
None listed