End Stage Renal Disease
Conditions
Keywords
hemodiafiltration, super high-flux hemodialysis, advanced glycation end products
Brief summary
The goal of this clinical trial is to compare efficacy in advanced glycation end products removal between Super high-flux Hemodialysis and high-volume post-dilution online hemodiafiltration. The main question it aims to answer are * Efficacy : endothelial dysfunction biomarker (AGEs) in super high-flux hemodialysis compared to online HDF * Safety profile : Dialysate albumin loss, Intradialytic complication Participants will be asked to randomized in 2 groups : Super high-flux HD or post dilution ol-HDF Researchers will compare SHF-HD and ol-HDF to see whether SHF-HD could remove AGEs better than ol-HDF
Interventions
Super high-flux hemodialysis (SHF-HD) is hemodialysis using Super high-flux dialyzer for 24 week then crossover to post dilution online HDF (wash out period 4 weeks)
DEVICEpostdilution online hemodiafiltration
hemodialysis by post dilution online HDF technique for 24 week then crossover to super high-flux HD (wash out period 4 weeks)
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Chronic HD \> 3 months * Adequate small molecule uremic toxins removal * Kt/v \> 1.8 in HD 2 times/week * Kt/v \> 1.2 in HD 3 times/week * BFR \> 300 mL/min * RKF \< 100 ml/day * Hemodynamically stable for \> 2 weeks
Exclusion criteria
* contraindicated to anticoagulant * active malignancy * advanced liver disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| skin autofluorescence for AGEs | 24 weeks | SAF was measured by using a certified Autofluorescence Reader (AGE Reader, DiagnOptics, Groningen, The Netherlands). The AGEs reader uses an excitation light source between 300 and 420 nm to illuminate a skin surface that is about 1 cm2 in size and shielded from outside light. A spectrometer (AVS-USB2000, Avantes Inc., Eerbeek, The Netherlands) is used to measure the emission light from the skin in the 300- to 600-nm region using a 200-mm glass fiber. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| serum beta 2 microglobulin | At first week, 8th week, 16th week and 24th week | Measure mid-week prehemodialysis serum beta2 micro globulin |
Countries
Thailand
Outcome results
None listed