Anesthesia, Ringer's Lactate
Conditions
Brief summary
* To compare the effect (heart rate and mean arterial pressure) of Ringer Lactate preloading and without preloading on induction dose requirement of Propofol. * The Propofol requirement for induction dose with respect to loss of eyelash reflex in Ringer Lactate preloaded versus control group.
Detailed description
1. From the operation list, patients that meet the Inclusion criteria will be selected. (n=60) 2. Patients will be allocated into two participant groups. Group I and Group II respectively using Simple random sampling technique by Ballot method. Ballot method is to keep the list of patients that meet the inclusion criteria in two ballot box mentioning name and groups and do the lottery based selection for both groups and Patient code will be given. 3. Group I (n = 30) Preloading with Ringer Lactate 30 ml/kg over 30 mins prior to surgery will be done and Propofol dose (2mg / kg ) requirement for induction of anaesthesia will be noted. Group II (n = 30) No Preloading will be done and Propofol dose (2mg / kg) requirement for induction of anaesthesia will be noted. 4. Then, investigators will visualize for loss of eyelash reflex in both groups. 5. The hemodynamic response (heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure) to intubation between the two participant groups will be noted. The total Propofol requirement for induction in Ringer Lactate preloaded versus control group will be recorded. 6. Drug administration and parameters recording will be done by the anaesthesiologist / under supervision
Interventions
DRUGRinger Lactate prior to surgery and Propofol
Ringer Lactate prior to surgery and Propofol dose requirement for induction of anaesthesia will be noted
Sponsors
National Medical College Birgunj
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
1. Patients scheduled for elective surgeries 2. American Society of Anaesthesiologists (ASA) class I patients 3. Age between 18-45 years 4. Any surgery under general anaesthesia requiring endotracheal intubation 5. Body mass index (BMI) -18.5 - 24.9 6. Those providing written consent
Exclusion criteria
1. Emergency surgery 2. Patients with multiple injuries, pregnancy 3. Airway Mallampati grade II, III and IV 4. Allergy to Ringer Lactate and Propofol.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Propofol dose Required (mg) | Standard dosing in Operation | Propofol dose (mg) with aspect to weight (kg) |
| Total Propofol dose given (mg) | Visualization of loss of eyelash reflex | Propofol dose (mg) |
| Loss of eyelash reflex (seconds) | Propofol given till loss of eyelash reflex | Visualization of loss of eyelash reflex (seconds) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate (beats / minute): At intubation (0 minute) | At intubation (0 minute) | Heart rate (beats / minute) will be measured with pulse oxymeter |
| Heart rate (beats / minute): Post intubation (1 minute) | Post intubation (1 minute) | Heart rate (beats / minute) will be measured with pulse oxymeter |
| Heart rate (beats / minute): Post intubation (3 minute) | Post intubation (3 minute) | Heart rate (beats / minute) will be measured with pulse oxymeter |
| Heart rate (beats / minute): Post intubation (5 minute) | Post intubation (5 minute) | Heart rate (beats / minute) will be measured with pulse oxymeter |
| Heart rate (beats / minute): Post intubation (10 minute) | Post intubation (10 minute) | Heart rate (beats / minute) will be measured with pulse oxymeter |
| Systolic blood pressure (mm Hg): Baseline before IV fluid infusion | Baseline before IV fluid infusion | Systolic blood pressure (mm Hg) will be recorded on vital monitor |
| Systolic blood pressure (mm Hg): After IV Propofol | Immediately After IV Propofol | Systolic blood pressure (mm Hg) will be recorded on vital monitor |
| Systolic blood pressure (mm Hg): At intubation (0 minute) | At intubation (0 minute) | Systolic blood pressure (mm Hg) will be recorded on vital monitor |
| Systolic blood pressure (mm Hg): Post intubation (1 minute) | Post intubation (1 minute) | Systolic blood pressure (mm Hg) will be recorded on vital monitor |
| Systolic blood pressure (mm Hg): Post intubation (3 minute) | Post intubation (3 minute) | Systolic blood pressure (mm Hg) will be recorded on vital monitor |
| Systolic blood pressure (mm Hg): Post intubation (5 minute) | Post intubation (5 minute) | Systolic blood pressure (mm Hg) will be recorded on vital monitor |
| Systolic blood pressure (mm Hg): Post intubation (10 minute) | Post intubation (10 minute) | Systolic blood pressure (mm Hg) will be recorded on vital monitor |
| Diastolic blood pressure (mm Hg): Baseline before IV fluid infusion | Baseline before IV fluid infusion | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Units of Measure (e.g., weight and height) | Preanaesthetic checkup, Day 1 | Weight in kilograms, height in meters ( weight and height will be combined to report BMI in kg/m²). |
| Diastolic blood pressure (mm Hg): At intubation (0 minute) | At intubation (0 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Diastolic blood pressure (mm Hg): Post intubation (1 minute) | Post intubation (1 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Diastolic blood pressure (mm Hg): Post intubation (3 minute) | Post intubation (3 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Diastolic blood pressure (mm Hg): Post intubation (5 minute) | Post intubation (5 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Diastolic blood pressure (mm Hg): Post intubation (10 minute) | Post intubation (10 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Mean arterial pressure (mm Hg): After IV Propofol | Immediately After IV Propofol | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Mean arterial pressure (mm Hg): Baseline before IV fluid infusion | Baseline before IV fluid infusion | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Mean arterial pressure (mm Hg): At intubation (0 minute) | At intubation (0 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Mean arterial pressure (mm Hg): Post intubation (1 minute) | Post intubation (1 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Mean arterial pressure (mm Hg): Post intubation (3 minute) | Post intubation (3 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Mean arterial pressure (mm Hg): Post intubation (5 minute) | Post intubation (5 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Mean arterial pressure (mm Hg): Post intubation (10 minute) | Post intubation (10 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Diastolic blood pressure (mm Hg): After IV Propofol | Immediately After IV Propofol | Diastolic blood pressure (mm Hg) will be recorded on vital monitor |
| Heart rate (beats / minute): After IV Propofol | Immediately After IV Propofol | Heart rate (beats / minute) will be measured with pulse oxymeter |
| Heart rate (beats / minute): Baseline before IV fluid infusion | Base line Before IV fluid infusion | Heart rate (beats / minute) will be measured with pulse oxymeter |
Countries
Nepal
Contacts
Primary ContactDr Arushi Jaiswal
Outcome results
None listed