Patella; Tendinitis
Conditions
Brief summary
The goal of this clinical trial is to examine the regional protein turnover in tendon tissue from patients with chronic patellar tendinopathy and comparing this to healthy controls. Further we will examine the effect of resistance training on protein turnover in healthy individuals.
Interventions
OTHERProgressive resistance training
Only the control group: 3 exercise bouts within the study period. Comparison between exercised and non-exercised leg.
OTHERCross-sectional comparison between healthy and tendinopathic group
Comparison of primary and secondary outcomes.
Sponsors
Bispebjerg Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Physical active men and women * Body mass index 18,5 - 30 kg/m2 Inclusion Criteria for the chronic tendinopathy group: * Debut of symptom \> 90 days prior to inclusion. * Subjective activity related pain in patella tendon. * Clinical symptoms of patella tendinopathy. * Ultrasound verification of at least 1 in three of the following: Enchanced anterior-posterior diameter, increased Doppler signal and/or a hypoechoic area in the diseased part of the tendon.
Exclusion criteria
for all participants: * Former knee surgery or injuries to the patella tendon. * Local injection of corticosteroids within 12 months. * Medication that affects protein synthesis in tendon tissue. * Former/current use of anabolic steroids or growth hormone. * Smoking * Known rheumatoid disease or diabetes. * Former participation in trials using deuterated water and 15N tracers. * Treatment for patella tendinopathy within 3 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Protein turnover in tendon tissue from patients with chronic tendinopathy compared to healthy controls | 8 days | Fractional synthesis rate (FSR) measured in % pr. day in the trypsin-soluble and trypsin-insoluble fraction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Anterior-posterior dimensions of patella tendon | 8 days | Measured in millimeter |
| Doppler flow in patella tendon | 8 days | Classified in grading system from 0-3. |
| Subjective pain in patella tendon | 8 days | Questionnaire |
| Tracer incorporation in isolated fractions of the tendon | 8 days | 15N hydroxyproline enrichment measured in Mole percent Excess in the trypsin-soluble and trypsin-insoluble fraction |
| Single-leg decline squat test | 1 day | Subjective pain on a scale from 0-10 |
| One leg knee extension strength test | 8 days | Only control-group. |
| Leg press strength test | 8 days | Only control-group. |
| Subjective measure of physical activity and function | 1 day | Questionnaire |
Countries
Denmark
Outcome results
None listed