The Effect of Hyaluronic Acid Gel on Relieving Post-Implantation Pain

Evaluation of the Efficacy of a Hyaluronic Acid Gel in Relieving Post-Implantation Pain: A Split-Mouth Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05776290

Enrollment

Registered

2023-03-20

Start date

2021-02-15

Completion date

2022-05-15

Last updated

2023-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Implant Complication

Brief summary

Few previous studies have employed HA in the implant socket; instead, the majority have applied it topically to the area around dental implants after they have been placed. The application was done after suturing in these investigations. Therefore, the goal of the current study was to inject HA into the implant socket and onto the alveolar bone prior to implant insertion and suturing in order to preserve the HA for an extended period of time. This study aims to use a visual analog scale (VAS) on the first, third, and tenth days following the surgical intervention to assess the efficacy of employing HA in dental implants in terms of pain reduction that may accompany dental implant surgery.

Interventions

BIOLOGICALHyaluronic Acid

This material will be injected into the prepared impact socket prior to inserting the implant. This injection will be done inside the socket as well as on the periphery of the socket.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Intervention model description

Split mouth design

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* bilateral tooth loss with a sufficient amount of bone volume * no general problems * good oral health * age between 20 and 60 years

Exclusion criteria

* the use of immunosuppressive drugs and corticosteroids for long periods * the existence of serious systemic disorders * contraindications for local anesthesia or oral surgery * pregnant women and nursing mothers * patients receiving chemotherapy or radiation * alcoholics and heavy smokers.

Design outcomes

Primary

Measure	Time frame	Description
Change in the Perception of pain	First assessment: at 24 hours following the surgical procedure. Second assessment: at 72 hours following the surgical intervention. Third assessment will be made on the tenth day following the surgical intervention	This will be measured using a numeric rating scale. Patients will be asked to indicate the level of pain they perceive on a scale from 1 to 10. The intensity of pain is going to be classified according to the following categories: 0 = no pain, 1-3 = mild pain, 3-6 = moderate pain, and 6-10 = severe pain.

Countries

Syria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026