Heart Failure
Conditions
Keywords
Heart transplantation, Heart failure, Prognosis
Brief summary
Heart transplantation is the most effective treatment for end-stage heart failure, advanced cardiomyopathy, and complex congenital heart disease with severe heart failure or hypoxia. Several clinical studies have shown significant differences in the prognosis of heart transplantation patients with different etiologies, and post-transplantation complications are an important factor affecting patient survival, and there is still a lack of overall prognostic stratification and extensive clinical studies on risk factors after heart transplantation. Therefore, this study is intended to include patients who underwent heart transplantation for different etiologies of heart failure, collect clinical data and biological samples from patients, and use various techniques to deeply interpret the risk factors affecting the prognosis of heart transplantation patients and construct a prognostic prediction model to provide specific and individualized treatment ideas and theoretical basis for improving the survival rate of patients after heart transplantation.
Interventions
None listed
Sponsors
First Affiliated Hospital Xi'an Jiaotong University
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
3 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients with end-stage heart failure presented to our hospital who are evaluated by clinicians and ethically approved for heart transplantation * Individuals whose hearts are donated
Exclusion criteria
* Patients refuse to sign informed consent form
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in the incidence of all-cause death | In-hospital (an average of 1 month), 1, 2, 3, 5, 10, 15 and 20 years after heart transplantation. | Death from any cause in patients after heart transplantation, will be assessed from medical records. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Use of advanced life support (ALS) | In-hospital (an average of 1 month) | Duration of ALS after heart transplantation, will be assessed from medical records. |
| Incidence of postoperative complications | In-hospital (an average of 1 month) | Postoperative complications after heart transplantation will be assessed from medical records. |
| ICU admission time | In-hospital (an average of 1 month) | ICU admission time after heart transplantation, will be assessed from medical records. |
| Change of cardiac function index | In-hospital (an average of 1 month). | Cardiac functional index after heart transplantation will be assessed by transthoracic echocardiography. |
Countries
China
Contacts
Primary ContactGuoliang Li
Backup ContactYang Yan
Outcome results
None listed