Validation of UK Protocols to Exclude Brain Blood Flow During Normothermic Regional Perfusion (NRP)

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05775263

Enrollment

Registered

2023-03-20

Start date

2024-06-01

Completion date

2025-06-01

Last updated

2023-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Blood Flow

Brief summary

This study aims to evaluate both Abdominal Normothermic Regional Perfusion (A-NRP) and Thoracoabdominal-NRP (TA-NRP) techniques, proving that brain blood flow is not resumed during NRP. This will be assessed through the use of two modalities: CT angiogram of the brain and continuous Hb02 readings. The study group hypothesise that such assessment methods will provide evidence to indicate that brain blood flow is not present during NRP and promote trust in the use of such novel techniques in routine practice.

Interventions

PROCEDURECT angiogram

CT angiography of the brain 30 minutes from establishment of NRP

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* DCD donors in Cambridge University Hospital * Planned A-NRP * Consent for study has been obtained * Those who meet the appropriate criteria for DCD donation following WOLST * ≥ 18 years of age * ≤ 75 years of age

Exclusion criteria

* DBD organ donors * DCD organ donations outside of Cambridge University Hospital * DCD donors without planned A-NRP * DCD donors whose family have withheld consent for brain blood flow investigations. * Patients who do not meet the appropriate criteria for DCD donation following WOLST * Patients with injuries that will physically prevent use of the necessary assessment methods

Design outcomes

Primary

Measure	Time frame	Description
CT angiogram	30 minutes from establishment of NRP	Brain blood flow

Secondary

Measure	Time frame	Description
Cerebral oximetry	Prior to withdrawal of life sustaining treatment to 30 minutes after establishment of NRP	HbO2 measurements (O2Hbi (Delta oxygenated), HHbi (Delta deoxygenated), and cHbi (Delta total))

Contacts

Primary ContactAntonio Rubino

a.rubino@nhs.net01223 639574

Backup ContactThomas Howlett

thomas.howlett@nhs.net

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026