Obesity, Weight Loss
Conditions
Keywords
gastric myoelectric activity, Inflammatory, bariatric surgery, lifestyle intervention, weight loss, body composition
Brief summary
Gastric myoelectric, inflammatory, and hormonal responses, body compositional, energy expenditure, and metabolic changes during the development of obesity and the weight loss process are underinvestigated. This project studied the myoelectrical inflammatory and hormonal responses of the stomach, in addition to energy expenditure and body composition changes during weight loss via bariatric surgery and lifestyle intervention.
Detailed description
Gastric myoelectric, inflammatory, and hormonal responses, body compositional, energy expenditure, and metabolic changes during the development of obesity and the weight loss process are underinvestigated. This project studied the myoelectrical, inflammatory, and hormonal responses of the stomach, in addition to energy expenditure and body composition changes during weight loss via bariatric surgery and lifestyle intervention. Methods: We recruited 79 participants who were assigned to three groups: bariatric surgery (BS group n=27), lifestyle intervention (LS group, n=22), and waitlist control (C group n=30). For all participants, electrogastrography, inflammatory cytokines, gastric hormones analysis, body composition analysis, energy expenditure, and dietary assessment were done at baseline and at 6 months.
Interventions
PROCEDURESleeve gastrectomy
laparoscopic sleeve gastrectomy was done under general anesthesia by the same surgeon in the SBAHC. Routine preoperative, and postoperative care (including early post-operative dietary management) were done. Baseline assessment was taken within the last week before the surgery during the preoperative preparation and the final assessment was recorded 6 months after the surgery date.
DIETARY_SUPPLEMENTLifestyle intervention
balanced 500 to 1000-calorie-deficit diet, personalized physical activity plan, and customized behavioral modification
OTHERControl
No interventions were applied
Sponsors
King AbdulAziz City for Science and Technology
King Saud University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* BMI \> 35 kg/m2, * Being free of any acute medical condition, inflammatory conditions, malignancy, or psychiatric disorders
Exclusion criteria
* Taking weight-losing pharmacotherapy * Who underwent previous bariatric surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gastric myoelectric activity | 6 months | The gastric myoelectric activity was measured in fasting (for 10 mins) and post-prandial state (for 30 mins) using a multichannel electrogastrography (EGG) with a water load satiety test |
| Inflammatory changes | 6 months | Serum levels of inflammatory markers involving interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and monocyte chemoattractant protein (MCP-1), |
| Body composition measurement | 6 MONTHS | Body composition was analyzed via a multi-Frequency segmental bioelectric impedance analysis monitor |
| Resting Energy Expenditure | 6 MONTHS | Resting metabolic rate (RMR) was measured by the automated metabolic cart indirect calorimetry (IC) using a standard canopy hood |
| hormonal analysis | 6 Months | serum levels of ghrelin, gastrin, and irisin (ELISA kits MyBiosource, San Diego, CA, USA; Catalog numbers: MBS2700428, MBS264399, MBS2600406, respectively). |
Countries
Saudi Arabia
Outcome results
None listed