Chronic Obstructive Pulmonary Disease
Conditions
Brief summary
The goal of observational study is to evaluate effectiveness of predicting the integrity of interlobar fissures based on chest image AI technology in patients with Chronic Obstructive Pulmonary Disease who will undergo lung volume reduction surgery with endobronchial valve implantation. The main question it aims to answer is: evaluation of the effectiveness of predicting the integrity of interlobar fissures based on chest image AI technology. Participants will be evaluated by lung CT (quantitative analysis based on chest image AI technology and artificial analysis) and imported Chartis detection system.
Interventions
OTHEREmphysema quantitative analysis software based on chest image AI technology
The participants would undergo lung CT, and the integrity of interlobar fissure will be quantitatively analyses by software based on chest image AI technology.
OTHERartificial analysis of chest image
The participants would undergo lung CT, and the integrity of interlobar fissure will be artificially analyses.
PROCEDUREimported Chartis detection system
The participants would undergo imported Chartis detection system.
Sponsors
China-Japan Friendship Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients with chronic obstructive pulmonary disease who meet the GOLD diagnostic criteria * FEV1 ≤ 45% pred and FEV1/FVC\<70% * TLC\>100% pred and RV\>175% pred * CAT≥18 * \>50% of emphysema destruction * Smoking prohibition\>6 months * Sign the informed consent form
Exclusion criteria
* PaCO2\>8.0 kPa, or PaO2\<6.0 kPa * 6-minute walking test\<160m * Obvious chronic bronchitis, bronchiectasis or other infectious lung diseases * Three hospitalizations due to pulmonary infection in the past 12 months before the baseline assessment * Previous lobectomy, LVRS or lung transplantation * LVEF\<45% and or RVSP\>50mmHg * Anticoagulant therapy that cannot be stopped before surgery * The patient has obvious immune deficiency * Participated in other lung drug studies within 30 days before this study * Pulmonary nodules requiring intervention * Any disease or condition that interferes with the completion of the initial or subsequent assessment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Therapeutic effect of lung volume reduction surgery | 1 month after bronchoscopic valve lung volume reduction | Lung CT |
| the integrity of interlobar fissure | Before bronchoscopic valve lung volume reduction | Emphysema quantitative analysis softwarebased on chest image AI technology, artificial analysis and imported Chartis detection system |
Outcome results
None listed