Fibromyalgia
Conditions
Brief summary
The hypersensitivity of fibromyalgia is associated with abnormal pain modulation within the CNS, but not with peripheral or central sensitization. Many brain areas that contribute to modulation of pain are known, but their testing is complex and expensive. Quantitative sensory testing is easier to perform and repeatable. Therefore, it will be used to evaluate the effects of Breathing Attention Training (BAT) on the hypersensitivity of FM participants. BAT is a form of mindfulness meditation shown to decrease FM symptoms and possibly pain sensitivity. We hypothesize that pain modulation of chronic pain patients is improved by BAT.
Interventions
BEHAVIORALBreathing and Attention Training (BAT)
BAT is an instructor guided breathing technique over 20 min that will be applied once in a training session and approximately one week later in a testing session.
BEHAVIORALBreathing Control
Controlled Breathing (without mindfulness) is an instructor guided breathing technique over 20 min that will be applied once in a training session and approximately one week later in a testing session.
Sponsors
University of Florida
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Masking description
Participants who do not receive BAT will be asked to perform deep breathing without mindfulness.
Intervention model description
This parallel study will be age & sex matched, and randomized.
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Individuals diagnosed with fibromyalgia will have pain of duration \> 6 months and meeting the 1990 Research Diagnostic Criteria for FM (ACR) * Healthy, pain-free age matched controls without chronic pain
Exclusion criteria
* Personal or family history of photosensitive epilepsy * Prior history of cancer or diabetes * Patients must be willing to discontinue their analgesics, hypnotics, anxiolytics, or anti-depressants during the study period for at least 5 half-lives.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ratings of Painful and Painless Sensory Stimuli | 2 hr | Ratings of painful and non-painful stimuli in FM subjects and HC will be obtained before and after BAT or Deep Breathing. Painful stimuli will include pressure stimuli. Painless stimuli will consist of flashing light stimuli. |
Countries
United States
Contacts
CONTACTMelyssa Godfrey
CONTACTRoland Staud, MD
PRINCIPAL_INVESTIGATORRoland Staud, MD
University of Florida
Outcome results
None listed