Bone Resorption, Calcium Metabolism Disorders, Eating, Healthy, Orthopedic Disorder, Water-Electrolyte Imbalance
Conditions
Brief summary
The experimental study investigates which metabolic responses of calcium and parathyroid hormone are observable in blood and urine in a cohort of 41 healthy adults following a sequence of different exposures: low-calcium water first and high-calcium water afterward.
Interventions
OTHERLoading of low-calcium water first, then high-calcium water
All cohort subjects are asked to consume water with less than 5 mg/L of calcium first, then are asked to consume water with at least 400 mg/L of calcium
Sponsors
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index ≥ 18 and \< 30 * Maintenance of diet and physical activity lifestyle throughout the duration of the study * Acceptance of informed consent
Exclusion criteria
* Consumption of water with calcium \> 150 mg/L * Pregnancy (as established by self-declaration), breastfeeding, menopause * Inability to follow the study protocol * Cardiac, vascular, renal, and oncological disease * Neuropsychiatric disease, developmental disorders * Disease or past surgery affecting the gastrointestinal tract * Drugs that interfere with bone (e.g. corticosteroids) or with fluid balance (e.g. diuretics)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of blood calcium levels | Baseline and 2.5 hours | Change of calcium levels (mg/dL) from baseline and after 2.5 hours |
Countries
Italy
Contacts
PRINCIPAL_INVESTIGATORMatteo Briguglio
IRCCS Istituto Ortopedico Galeazzi
Outcome results
None listed